About this Journal Submit a Manuscript Table of Contents
Journal of Allergy
Volume 2012 (2012), Article ID 509730, 7 pages
http://dx.doi.org/10.1155/2012/509730
Research Article

L-Carnitine Improves the Asthma Control in Children with Moderate Persistent Asthma

1Department of Paediatric, Faculty of Medicine, Tanta University, Tanta, P.o. box 1084, Gharbia Governate, Egypt
2Department of Paediatric, Abu Alrish Pediatric Hospital, Faculty of Medicine, Cairo University, Cairo, Egypt
3Department of Chest Diseases, Faculty of Medicine, Tanta University, Tanta, Gharbia Governate, Egypt
4Department of Clinical and Chemical Pathology, Medical Division, National Research Center, Cairo, Egypt

Received 7 April 2011; Revised 22 August 2011; Accepted 7 September 2011

Academic Editor: Mary Beth Hogan

Copyright © 2012 Mohammed Al-Biltagi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The objective. was to investigate L-Carnitine level and the effects of its supplementation in children with moderate persistent Asthma. Methods. Free and total serum carnitine levels were measured in 50 children having moderate persistent asthma and 50 healthy control children. The patients group was randomly divided into two subgroups. Subgroup A was supplemented with L-carnitine for 6 months while subgroup B was used as a placebo controls. Both subgroups were assessed by pulmonary function tests (PFT) and childhood-asthma control test (C-ACT) before and 6 months after carnitine supplementation. Results. Total and free carnitine levels were significantly lower in patient group than in control group. PFT and C-ACT showed significant improvements in asthmatic children supplemented with L-carnitine than in those who were not supplemented. Conclusion. L-carnitine levels were initially lower in moderate persistent asthmatic children as compared to healthy control children. Asthmatic children who received L-carnitine supplementation showed statistically significant improvement of C-ACT and PFT.