Research Article

Comparison of CD63 Upregulation Induced by NSAIDs on Basophils and Monocytes in Patients with NSAID Hypersensitivity

Table 4

Description of severe reactions (grade II) observed in patients with NSAID hypersensitivity.

Grade II reactions/time to onset*Visceral disorders (VD)
Laryngeal oedemaDyspnoea**HypotensionG-intestinal disordersAt least one VD***

<6 H 9 (43%) 8 (38%) 6 (29%) 3 (14%)21 (100%)
8 H 1 0 0 0 1

Total 10 (45%) 8 (37%) 6 (27%) 3 (14%) 22 (100%)

*Time to onset of symptoms after NSAID intake. **Dyspnoea observed in patients with no laryngeal oedema. ***Patients with a history of urticaria or angiooedema and with at least one visceral disorder were classified as having had a hypersensitivity of grade II according to published works [18].