Journal of Allergy

Research Article

Exhaled Eicosanoids following Bronchial Aspirin Challenge in Asthma Patients with and without Aspirin Hypersensitivity: The Pilot Study

Table 3

Eicosanoids values at baseline and following aspirin challenge in AIA and ATA patients. Results of eicosanoids were recalculated as picograms per milliliter (pg/mL).


	AIA ()		ATA ()		(ANOVA)
	Baseline	After the challenge	Baseline	After the challenge	After the challenge

PGD₂					0.35
(pg/mL)	1.01	1.21	1.64	1.53
GC/MS

PGD₂					0.05
(pg/mL)	1.39	1.09	1.48	1.45
HPLC

9α11βPGF₂					0.59
(pg/mL)	0.36	0.34	0.29	0.28
GC/MS

PGF2α					0.82
(pg/mL)	0.28	0.27	0.30	0.23
GC/MS

6-keto-PGF1α					0.53
(pg/mL)	7.17	7.22	7.48	7.46
GC/MS

6-keto-PGF1α					0.60
(pg/mL)	7.26	6.96	7.40	7.65
HPLC/MS/MS

11-dehydro TXB2	*		*		0.18
(pg/mL)	5.74	6.17	6.81	6.62
GC/MS

11-dehydro TXB2	*		*		0.03*
(pg/mL)	5.49	6.03	6.63	6.18
HPLC/MS/MS

LTC₄				*	0.01*
(pg/mL)	2.30	2.02	2.46	1.06
HPLC/MS/MS

LTD₄					0.16
(pg/mL)	0.69	0.65	1.34	0.95
HPLC/MS/MS

LTE₄		*		*	0.04*
(pg/mL)	1.83	2.33	1.93	2.45
HPLC/MS/MS

Total cysLTs					0.24
(pg/mL)	5.97	6.01	7.24	4.90
HPLC/MS/MS

LTB₄		*			0.02*
(pg/mL)	29.66	16.99	27.73	15.35
HPLC/MS/MS

5 HETE					0.79
(pg/mL)	2.94	3.41	2.29	1.67
HPLC/MS/MS

12 HETE				*	0.02*
(pg/mL)	4.05	2.82	3.10	1.93
HPLC/MS/MS

15 HETE	*		*		0.30
(pg/mL)	5.96	4.77	2.95	2.39
HPLC/MS/MS

EXC₄					0.74
(pg/mL)	0.79	0.59	0.80	0.61
HPLC/MS/MS

EXD₄					0.909
(pg/mL)	0.73	0.62	1.06	0.74
HPLC/MS/MS

EXE₄					0.07
(pg/mL)	2.15	1.05	1.59	1.35
HPLC/MS/MS

8-iso-PGF2α	*		*		0.92
(pg/mL)	0.20	0.21	0.35	0.34
GC/MS

Median (25% and 75% percentiles).
AIA: aspirin-induced asthma. ATA: aspirin-tolerant asthma.
* -values < 0.05; AIA versus ATA at baseline or after the challenge.
-values:
* AIA versus ATA at baseline.
*baseline versus challenge in AIA.
*baseline versus challenge in ATA.