Journal of Allergy / 2013 / Article / Tab 1 / Review Article
Adiponectin, Leptin, and Resistin in Asthma: Basic Mechanisms through Population Studies Table 1 A tabular summary of the current evidence supporting the roles for systemic adiponectin or leptin with respect to asthma in human subpopulations.
Adiponectin-asthma association Leptin-asthma association Asthma prevalence Asthma severity Asthma prevalence Asthma severity Males Prepubertal boys Inadequately studied (#) Beneficial effect on exercise induced bronchoconstriction and
[55 , 56 ] (*) Harmful effect [57 –59 ] (†) Harmful effect on clinical outcomes; peak expiratory flow rates; exercise induced bronchoconstriction [56 , 60 , 61 ] (†) Peri/postpubertal boys No effect [55 ] (‡) Beneficial effect on clinical outcomes and FEV1 /FVC ratio [62 ] (*) No effect [55 ] (‡) No effect [62 ] (‡) Men Unclear effect—no effect on clinical outcomes [63 , 64 ]; harmful effect on prevalent reversible airflow obstruction; beneficial effect on exhaled nitric oxide [63 , 65 ] (‡) Harmful effect on clinical outcomes [49 ] (†) No effect [64 –66 ] (‡) Inadequately studied (#) Females Prepubertal girls Inadequately studied (#) Inadequately studied (#) Inadequately studied (#) Harmful effect on clinical outcomes [61 ] (†) Peri/postpubertal girls Beneficial effect [67 ] (*) Possible beneficial effect on clinical outcomes and spirometry [68 ] (*) Harmful effect [67 ] (†) Harmful effect on clinical outcomes [62 ] (†) Premenopausal women Beneficial effect [36 , 63 , 69 ] (*) Beneficial effect on clinical outcomes [49 ] (*) Harmful effect [66 ] (†) Inadequately studied (#) Postmenopausal women Inadequately studied (#) Beneficial effect on clinical outcomes [70 ] (*) Harmful effect [70 ] (†) Harmful effect on clinical outcomes and FEV1 /FVC ratio [70 ] (†)
Note 1: Inadequately studied, beneficial; and harmful associations as well as no effects or unclear effects are depicted by different symbols (#, *, †, and ‡).