Treatment of Allergic Rhinitis with Ectoine Containing Nasal Spray and Eye Drops in Comparison with Azelastine Containing Nasal Spray and Eye Drops or with Cromoglycic Acid Containing Nasal Spray

Table 1

Development of single nasal scores (mean ± SD) during study 1 according to patients’ and investigators’ assessments.

Symptom	Group	Score d1 (patient)	Score d7 (patient)	𝑃 value	Score V1 (investigator)	Score V2 (investigator)	𝑃 value
Nasal obstruction	Ectoine	4.14±1.93	3.38±2.20	𝑃=0.003	5.29±1.15	2.86±1.49	𝑃<0.001
	Azelastine	4.38±2.38	3.60±2.37	𝑃=0.044	5.91±1.23	3.0±2.13	𝑃<0.001
Rhinorrhea	Ectoine	3.81±1.86	2.71±1.87	𝑃=0.054	5.19±1.03	2.24±1.58	𝑃<0.001
	Azelastine	3.48±2.11	2.8±2.02	𝑃=0.133	5.45±1.01	2.59±1.89	𝑃<0.001
Sneezing	Ectoine	3.9±1.92	2.9±1.73	𝑃=0.475	6.0±1.48	2.43±1.58	𝑃<0.001
	Azelastine	4.05±1.43	2.45±1.7	𝑃<0.001	5.77±0.92	2.32±2.10	𝑃<0.001
Nasal itching	Ectoine	2.81±1.83	2.05±1.56	𝑃=0.068	4.24±2.32	1.00±1.41	𝑃=0.001
	Azelastine	3.90±1.70	2.25±1.92	𝑃=0.002	4.59±1.99	1.41±1.05	𝑃<0.001