The Catalytic Machinery of a Key Enzyme in Amino Acid Biosynthesis

Figure 5

Differences in coenzyme binding in ASADHs. An overlay of the NADP binding orientations in V. cholerae ASADH (blue), S. pneumonia ASADH (red), and C. albicans ASADH (green). The center of the adenine ring in the Gram-positive and fungal enzymes has shifted by about 8.5 Å with respect to its position in vcASADH, and the position of the exocyclic amine on C6 has moved by nearly 14 Å (figure adapted from reference [20]).