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Journal of Amino Acids
Volume 2011 (2011), Article ID 517137, 5 pages
http://dx.doi.org/10.4061/2011/517137
Research Article

Peptides Regulate Cortical Thymocytes Differentiation, Proliferation, and Apoptosis

1Saint-Petersburg Institute of Bioregulation and Gerontology, RAMS pr. Dinamo 3, St. Petersburg 197110, Russia
2I.P. Pavlov Institute of Physiology, RAS, Makarova emb. 6, St. Petersburg 199034, Russia

Received 16 May 2011; Revised 6 July 2011; Accepted 12 September 2011

Academic Editor: Udupi A. Ramagopal

Copyright © 2011 V. Kh. Khavinson et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The processes of differentiation, proliferation, and apoptosis were studied in a cell culture of human cortical thymocytes under the influence of short peptides T-32 (Glu-Asp-Ala) and T-38 (Lys-Glu-Asp). Peptides T-32 and T-38 amplified cortical thymocytes differentiation towards regulatory T cells, increased their proliferative activity, and decreased the level of apoptosis. Moreover, peptides under study stimulated proliferative and antiapoptotic activity of the mature regulatory T cells.