531412.fig.001a
(a)
531412.fig.001b
(b)
Figure 1: A cartoon representation of (a) ABC and (b) MFS transporters of Candida. The topology of ABC and the MFS transporters depicted here have the (NBD-TMS6)2 and the (TMS)12 (Transmembrane Segments) arrangements, respectively. The NBDs (Nucleotide-Binding Domains) of the ABC transporters are responsible for the hydrolysis of ATP, which facilitates drug extrusion while the MFS transporters utilize proton gradient to expel drugs.