Metal Preferences of Zinc-Binding Motif on Metalloproteases

Table 3

Reactivated Co(II) and Mn(II) enzymes substituted from apo-metalloproteases.

Clan	Subclan	Name of enzyme	Replaced Ion	Reference
MA	E	Aminopeptidase Ey	Co^2+, Mn^2+	Tanaka and Ichishima [21]
MA	E	Aminopeptidase B	Co^2+	Hirose et al. [22]
MA	E	Saccharolysin	Co^2+, Mn^2+	Achstetter et al. [23] and Büchler et al. [24]
MA	E	Lysyl aminopeptidase	Co^2+, Mn^2+	Klein et al. [25]
MA	E	Oligopeptidase F	Co^2+, Mn^2+	Yan et al. [26] and Monnet et al. [27]
MA	E	Mycolysin (Thermolysin)	Co^2+, Mn^2+ Co^2+ (200%), Mn^2+ (10%)	Chang and Lee [28], and Holmquist and Vallee [29]
MA	E	Oligopeptidase O	Co^2+; Mn^2+ (50%)	Tan et al. [30] and Baankreis et al. [31]
MA	E	Hyicolysin	Co^2+	Ayora and Götz [32]
ME	E	Legionella metalloendopeptidase	Mn^2+ (69%)	Dreyfus and Iglewski [33]
MA	A	Epralysin	Co^2+ (58%)	Diermayr et al. [34]
MA	M	Astacin	Co^2+ (140%)	Gomis-Rüth et al. [5]
MA	M	MEP^a (𝐺𝑓^b MEP)	Co^2+; Mn^2+ (200%)	Nonaka et al. [35]
MA	M	𝑃𝑜^c MEP	Co^2+ (80%); Mn^2+ (30%)	Nonaka et al. [35]

^aPeptidyl-Lys metallopeptidase; ^bGrifola frondosa; ^cPleurotus ostreatus.