Review Article
Serpin Inhibition Mechanism: A Delicate Balance between Native Metastable State and Polymerization
Table 4
Analysis of the residue burial and stability of natural variant of serpin involved in polymerization.
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aTwo different variant at the same position. bAccessible Surface Area (ASA) values were determined from DSSP algorithm. The pdb codes used for the analysis are as follows: antithrombin (1t1f), antitrypsin (1qlp), neuroserpin (1jjo and 3fgq), antichymotrypsin (1yxa), and heparin cofactor-II (1jmj). cΔΔG were determined for the variants by using Imutant 2.0 at pH 7.0 and 25°C, the values were determined by using the difference of ΔG between the wild-type and the polymerization variants mentioned in the table. |