Table 1: Mutations in the conserved ATP binding/hydrolysis domain and phenotypes in GroEL and three subunits of CCT complex.

SubunitAmino acid replacementPhenotypeReferences

GroELG35ENormal[96]
GroELD87NLethal[96]
GroELD87KLethal[96]
Cct1pG45SCS[93]
Cct1pG48EHS[92]
Cct1pD96ECS[93]
Cct1pG423DHS[93]
Cct2pG41ELethal[94]
Cct6pG38SNormal[95]
Cct6pG41ETBZS, NaClS[95]
Cct6pG59RTBZSS, NaClS[95]
Cct6pD89ETBZS[95]
Cct6pG90ETBZSS, NaClS[95]
Cct6pG414ECS[95]
Cct6pG416DNormal[95]
Cct6pG416ECS[95]

CS: Cold sensitive; HS: heat sensitive; TBZS: Thiabendazole sensitive; TBZSS: Thiabendazole-hyper sensitive; NaClS: Sodium chloride sensitive.