356081.fig.002a
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356081.fig.002b
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356081.fig.002c
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Figure 2: Genetic interactions of TDP-43/TBPH. (a) Schematic representation describing the effects of valosin-containing protein (VCP7) gene overexpression on TDP-43-toxicity in Drosophila melanogaster. (b) Schematic representation describing the effects of FUS/TLS gene overexpression on TDP-43-toxicity in Drosophila melanogaster. (c) Schematic representation describing the effects of UBQLN gene overexpression on TDP-43-toxicity in Drosophila melanogaster. The lines of evidence supporting the genetic interaction between the TDP-43 and these other genes are schematically summarized.