In Vitro Activities of Kissorphin, a Novel Hexapeptide KiSS-1 Derivative, in Neuronal Cells

Figure 3

Effect of KSO, NPFF, and KP peptides on forskolin prevention of H₂O₂ toxicity in ND-7/23 cells. Cells were exposed to H₂O₂ either alone or in the presence of forskolin with KSO, NPFF, or KP peptides for 2 hours prior determination of cell viability by MTT reduction. The effects of the NPFF receptor antagonist RF9 and the GPR-54 antagonist KP234 were also determined. Results are expressed as % Control MTT reduction (mean ± sem; 𝑛=8). *𝑃<0.05 versus H₂O₂ alone; ^†𝑃<0.05 versus H₂O₂ plus forskolin; one-way ANOVA.