Review Article

Glutathione Homeostasis and Functions: Potential Targets for Medical Interventions

Figure 3

Involvement of glutathione in elimination of reactive oxygen and nitrogen species. Hydroxyl radical and nitric oxide (after oxidation to the NO+ form) or peroxynitrite may interact directly with GSH leading to GSSG formation. Hydrogen peroxide may be removed by catalase or by glutathione peroxidase (GPx). The latter requires GSH to reduce peroxide.
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