Amino Acid Derivatives as New Zinc Binding Groups for the Design of Selective Matrix Metalloproteinase Inhibitors

Table 3

Enzymatic inhibition of MMP-2 by 2-amino-1,3-disubstituted derivatives 1a–1l.

Compounds		R	R1	IC50 (μM ± SD)
	AHA			10000±630
	1a	OH	OH	280±24
	1b	CN	CN	560±52
	1c	N3	N3	>1000
	1d	SH	OH	674±88
	1e	Imidazole	OH	450±23
	1f	SH	SH	666±90
	1g	Imidazole	SH	300±41
	1h	SH	CN	500±49
	1i	OH	CN	807±98
	1j	SH	N3	520±57
	1k	OH	N3	520±49
	1l	Imidazole	N3	480±25