Amino Acid Derivatives as New Zinc Binding Groups for the Design of Selective Matrix Metalloproteinase Inhibitors

Table 4

Enzymatic activity of N-substituted phenoxybenzensulfonamide25a, 25d, and 25e on different MMPs.

Com.	R	R1	IC50 (μM ± SD)
			MMP-1	MMP-2	MMP-8	MMP-9
25a	OH	OH	1030±160	71±1.9	98±8.0	160±15
25d	SH	OH	819±116	110±10	9.1±2.3	12±4.0
25e	Imidazole	OH	480±30	190±8.7	330±21	200±15