DTNQ-Pro, a Mimetic Dipeptide, Sensitizes Human Colon Cancer Cells to 5-Fluorouracil Treatment
Figure 2
(a) Effects of 5-FU on the distribution of Caco-2 and D-Caco-2 cells populations. Data represent the percentage of cells in each phase of the cell cycle. Cell cycle distribution was determined by DNA flow cytometric analysis. Samples from preconfluent Caco-2 and D-Caco2 cells was analysed after 48 h of treatment with 500 nM 5-FU. Numbers indicate percentage of cells in G0/G1, S and G2/M phases. Data are representative of four separate analyses. (b) Differentiation effects of 5-FU of Caco-2 and D-Caco-2. The differentiation was assessed by measurement of ALP activity after 48 h of culture with 500 nM of 5-FU. Summary data shown are means ± SEM (; ).
