About this Journal Submit a Manuscript Table of Contents
Journal of Amino Acids
Volume 2013 (2013), Article ID 509056, 7 pages
http://dx.doi.org/10.1155/2013/509056
Research Article

DTNQ-Pro, a Mimetic Dipeptide, Sensitizes Human Colon Cancer Cells to 5-Fluorouracil Treatment

1Department of Pharmaceutical and Toxicological Chemistry, University of Naples Federico II, Naples, Italy
2Department of Pharmaceutical Sciences, University of Salerno, Fisciano, Salerno, Italy
3Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Naples, Italy
4Italian Institute for Auxology, IRCC, 20145 Milan, Italy

Received 1 February 2013; Accepted 27 March 2013

Academic Editor: Giuseppe De Rosa

Copyright © 2013 Isabel Gomez-Monterrey et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. G. Kuhn, “Fluorouracil and the new oral fluorinated pyrimidines,” Annals of Pharmacotherapy, vol. 35, no. 2, pp. 217–227, 2001. View at Scopus
  2. G. Vitale, C. H. J. van Eijck, P. M. van Koetsveld Ing et al., “Type I interferons in the treatment of pancreatic cancer: mechanisms of action and role of related Receptors,” Annals of Surgery, vol. 246, no. 2, pp. 259–268, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Marra, G. Salzano, C. Leonetti et al., “New self-assembly nanoparticles and stealth liposomes for the delivery of zoledronic acid: a comparative study,” Biotechnology Advances, vol. 30, no. 1, pp. 302–309, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Caraglia, G. Vitale, M. Marra, A. Budillon, P. Tagliaferri, and A. Abbruzzese, “Alpha-interferon and its effects on signalling pathways within cells,” Current Protein and Peptide Science, vol. 5, no. 6, pp. 475–485, 2004. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Marra, A. Lombardi, E. Agostinelli et al., “Bovine serum amine oxidase and spm potentiate docetaxel and interferon-α effects in inducing apoptosis on human cancer cells through the generation of oxidative stress,” Biochimica et Biophysica Acta, vol. 1783, no. 12, pp. 2269–2278, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Caraglia, M. Marra, P. Tagliaferri et al., “Emerging strategies to strengthen the anti-tumour activity of type I interferons: overcoming survival pathways,” Current Cancer Drug Targets, vol. 9, no. 5, pp. 690–704, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. C. Jolly and R. I. Morimoto, “Role of the heat shock response and molecular chaperones in oncogenesis and cell death,” Journal of the National Cancer Institute, vol. 92, no. 19, pp. 1564–1572, 2000. View at Scopus
  8. S. K. Calderwood, M. A. Khaleque, D. B. Sawyer, and D. R. Ciocca, “Heat shock proteins in cancer: chaperones of tumorigenesis,” Trends in Biochemical Sciences, vol. 31, no. 3, pp. 164–172, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. C. Garrido, A. Fromentin, B. Bonnotte et al., “Heat shock protein 27 enhances the tumorigenicity of immunogenic rat colon carcinoma cell clones,” Cancer Research, vol. 58, no. 23, pp. 5495–5499, 1998. View at Scopus
  10. S. Gurbuxani, J. M. Bruey, A. Fromentin et al., “Selective depletion of inducible HSP70 enhances immunogenicity of rat colon cancer cells,” Oncogene, vol. 20, no. 51, pp. 7478–7485, 2001. View at Publisher · View at Google Scholar · View at Scopus
  11. C. De Simone, P. Ferranti, G. Picariello et al., “Peptides from water buffalo cheese whey induced senescence cell death via ceramide secretion in human colon adenocarcinoma cell line,” Molecular Nutrition and Food Research, vol. 55, no. 2, pp. 229–238, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. R. Hayashi, Y. Ishii, H. Ochiai et al., “Suppression of heat shock protein 27 expression promotes 5-fluorouracil sensitivity in colon cancer cells in a xenograft model,” Oncology Reports, vol. 28, no. 4, pp. 1269–1274, 2012. View at Publisher · View at Google Scholar
  13. P. Mehlen, A. Mehlen, J. Godet, and A. P. Arrigo, “hsp27 as a switch between differentiation and apoptosis in murine embryonic stem cells,” Journal of Biological Chemistry, vol. 272, no. 50, pp. 31657–31665, 1997. View at Publisher · View at Google Scholar · View at Scopus
  14. D. R. Ciocca, S. Oesterreich, G. C. Chamness, W. L. McGuire, and S. A. W. Fuqua, “Biological and clinical implications of heat shock protein 27 000 (Hsp27): a review,” Journal of the National Cancer Institute, vol. 85, no. 19, pp. 1558–1570, 1993. View at Scopus
  15. P. Stiuso, G. Giuberti, A. Lombardi et al., “γ-Glutamyl 16-diaminopropane derivative of vasoactive intestinal peptide: a potent anti-oxidative agent for human epidermoid cancer cells,” Amino Acids, vol. 39, no. 3, pp. 661–670, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. L. Vigh, B. Maresca, and J. L. Harwood, “Does the membrane's physical state control the expression of heat shock and other genes?” Trends in Biochemical Sciences, vol. 23, no. 10, pp. 369–374, 1998. View at Publisher · View at Google Scholar · View at Scopus
  17. Z. Török, N. M. Tsvetkova, G. Balogh et al., “Heat shock protein coinducers with no effect on protein denaturation specifically modulate the membrane lipid phase,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 6, pp. 3131–3136, 2003. View at Publisher · View at Google Scholar
  18. E. Nagy, Z. Balogi, I. Gombos et al., “Hyperfluidization-coupled membrane microdomain reorganization is linked to activation of the heat shock response in a murine melanoma cell line,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 19, pp. 7945–7950, 2007. View at Publisher · View at Google Scholar
  19. A. Budillon, F. Bruzzese, E. Di Gennaro, and M. Caraglia, “Multiple-target drugs: Inhibitors of heat shock protein 90 and of histone deacetylase,” Current Drug Targets, vol. 6, no. 3, pp. 337–351, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. G. Misso, G. Giuberti, A. Lombardi et al., “Pharmacological inhibition of HSP90 and ras activity as a new strategy in the treatment of HNSCC,” Journal of Cellular Physiology, vol. 228, no. 1, pp. 130–141, 2013. View at Publisher · View at Google Scholar
  21. M. Caraglia, M. Marra, A. Budillon et al., “Chemotherapy regimen GOLF induces apoptosis in colon cancer cells through multi-chaperone complex inactivation and increased Raf-1 ubiquitin-dependent degradation,” Cancer Biology and Therapy, vol. 4, no. 10, pp. 1159–1167, 2005. View at Scopus
  22. G. Vitale, S. Zappavigna, M. Marra et al., “The PPAR-gamma agonist troglitazone antagonizes survival pathways induced by STAT-3 in recombinant interferon-gamma treated pancreatic cancer cells,” Biotechnology Advances, vol. 30, no. 1, pp. 169–184, 2012.
  23. G. L. Johnson and R. Lapadat, “Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases,” Science, vol. 298, no. 5600, pp. 1911–1912, 2002. View at Publisher · View at Google Scholar · View at Scopus
  24. M. G. Wilkinson and J. B. A. Millar, “Control of the eukaryotic cell cycle by MAP kinase signaling pathways,” The FASEB Journal, vol. 14, no. 14, pp. 2147–2157, 2000. View at Scopus
  25. S.-F. Chen, S. Nieh, S.-W. Jao et al., “Quercetin suppresses drug-resistant spheres via the p38 MAPK-Hsp27 apoptotic pathway in oral cancer cells,” PLoS ONE, vol. 7, no. 11, Article ID e49275, 2012. View at Publisher · View at Google Scholar
  26. I. Gomez-Monterrey, P. Campiglia, A. Bertamino et al., “A novel quinone-based derivative (DTNQ-Pro) induces apoptotic death via modulation/reduction of hsp expression in a human colon adenocarcinoma cell line,” British Journal of Pharmacology, vol. 160, no. 4, pp. 931–940, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. C. De Simone, G. Picariello, G. Mamone et al., “Characterisation and cytomodulatory properties of peptides from Mozzarella di Bufala Campana cheese whey,” Journal of Peptide Science, vol. 15, no. 3, pp. 251–258, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. F. Herz, A. Schermer, M. Halwer, and L. H. Bogart, “Alkaline phosphatase in HT-29, a human colon cancer cell line: Influence of sodium butyrate and hyperosmolality,” Archives of Biochemistry and Biophysics, vol. 210, no. 2, pp. 581–591, 1981. View at Scopus
  29. M. M. Bradford, “A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding,” Analytical Biochemistry, vol. 72, no. 1-2, pp. 248–254, 1976. View at Scopus
  30. Q. M. Ding, T. C. Ko, and B. Mark Evers, “Caco-2 intestinal cell differentiation is associated with G1 arrest and suppression of CDK2 and CDK4,” American Journal of Physiology, vol. 275, no. 5, pp. C1193–C1200, 1998. View at Scopus
  31. H. Matsumoto, R. H. Erickson, J. R. Gum, M. Yoshioka, E. Gum, and Y. S. Kim, “Biosynthesis of alkaline phosphatase during differentiation of the human colon cancer cell line Caco-2,” Gastroenterology, vol. 98, no. 5 I, pp. 1199–1207, 1990. View at Scopus
  32. D. A. Wink and J. B. Mitchell, “Chemical biology of nitric oxide: Insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide,” Free Radical Biology and Medicine, vol. 25, no. 4-5, pp. 434–456, 1998. View at Publisher · View at Google Scholar · View at Scopus
  33. H. Huang and D. J. Tindall, “Dynamic FoxO transcription factors,” Journal of Cell Science, vol. 120, no. 15, pp. 2479–2487, 2007. View at Publisher · View at Google Scholar · View at Scopus
  34. S. Popat, A. Matakidou, and R. S. Houlston, “Thymidylate-synthase expression and prognosis in colorectal cancer: a systematic review and meta-analysis,” Journal of Clinical Oncology, vol. 22, no. 3, pp. 529–536, 2004. View at Publisher · View at Google Scholar · View at Scopus
  35. L. Whitesell and S. L. Lindquist, “HSP90 and the chaperoning of cancer,” Nature Reviews Cancer, vol. 5, no. 10, pp. 761–772, 2005. View at Publisher · View at Google Scholar · View at Scopus