Design, Synthesis, and Evaluation of New Tripeptides as COX-2 Inhibitors
Figure 2
COX-1 (a) and (b) and COX-2 (c) and (d) recognition of GMD and GHE. Tripeptides are depicted in polytube CPK colored notation, interacting enzyme residues in green carbons wireframes, HEME cofactor in green carbons spacefill, and the rest of the enzyme is showed in transparent green cartoon. Yellow dotted lines indicated hydrogen bond interaction.
