An Amino Acids Mixture Improves the Hepatotoxicity Induced by Acetaminophen in Mice

Figure 2

Mortality rate in mice 8 h after acetaminophen (APAP, 8 mmol/kg ip) administration, alone or in presence of N-acetylcysteine (NAC; 3.6 mmol/kg ip), and a mixture of L-cysteine, L-methionine, and L-serine in ratio 2 : 1 : 1 (DDM-GSH; 1.6 mmol/kg ip). Saline (10 mL/kg), NAC, and DDM-GSH were given ip 1 h before APAP. 𝑛=10 mice/group. ^∗𝑃<0.05 and ^∗∗∗𝑃<0.001 versus saline; ^##𝑃<0.01 and ^###𝑃<0.001 versus APAP.