An Amino Acids Mixture Improves the Hepatotoxicity Induced by Acetaminophen in Mice

Figure 4

Total hepatic glutathione (GSH) in mice 8 h after acetaminophen (APAP, 2 mmol/kg ip) administration, alone or in presence of N-acetylcysteine (NAC) and a mixture of L-cysteine, L-methionine, and L-serine in ratio 2 : 1 : 1 (DDM-GSH). Saline (10 mL/kg), NAC, and DDM-GSH were given ip 1 h before APAP. 𝑛=10 mice/group. ^∗𝑃<0.05, ^∗∗𝑃<0.01, and ^∗∗∗𝑃<0.001 versus saline; ^#𝑃<0.05, ^###𝑃<0.01, and ^###𝑃<0.001 versus APAP.