An Amino Acids Mixture Improves the Hepatotoxicity Induced by Acetaminophen in Mice

Table 1

Body weight, liver weight, and survival rates in mice 8 h after administration of acetaminophen (APAP, 2 mmol/kg ip) alone or in presence of N-acetylcysteine (NAC) and a mixture of L-cysteine, L-methionine, and L-serine in a ratio 2 : 1 : 1 (DDM-GSH).

Treatment	Body weight (g)	Liver weight (g/10 g b.w.)	Survival rates (%)
Saline	23 ± 4	0.25 ± 0.01	100
APAP	24 ± 3	0.32 ± 0.01*	70*
NAC 0.9 mmol/kg + APAP	24 ± 3	0.30 ± 0.01*	90*
NAC 1.8 mmol/kg + APAP	23 ± 5	0.26 ± 0.03^#	100^#
NAC 3.6 mmol/kg + APAP	23 ± 4	0.26 ± 0.02^##	100^#
DDM-GSH 0.4 mmol/kg + APAP	25 ± 3	0.27 ± 0.02^#	100^#
DDM-GSH 0.8 mmol/kg + APAP	23 ± 2	0.24 ± 0.01^##	100^#
DDM-GSH 1.6 mmol/kg + APAP	26 ± 4	0.22 ± 0.02^###	100^#

Saline (10 mL/kg), NAC, and DDM-GSH were given ip 1 h before APAP. Values are reported as mean ± SE (𝑛 = 10 animals/group). *𝑃 < 0.05 versus saline; ^#𝑃 < 0.05, ^##𝑃 < 0.01, and ^###𝑃 < 0.001 versus APAP.