Ischemia Induces Release of Endogenous Amino Acids from the Cerebral Cortex and Cerebellum of Developing and Adult Mice

Table 2

Early and late ischemia-induced release of GABA, glutamate, and taurine.

	7-day-old mice		3-month-old mice
Amino acid	mmol/min/kg protein		mmol/min/kg protein
	Release period		Release period
	20–30 min	32–50 min	20–30 min	32–50 min
Cerebral cortex
GABA	0.108 ± 0.002	0.104 ± 0.001	0.429 ± 0.007	0.235 ± 0.024*
Glutamate	0.282 ± 0.010	0.171 ± 0.012*	0.671 ± 0.057	0.870 ± 0.015*
Taurine	3.357 ± 0.164	2.078 ± 0.100*	1.112 ± 0.061	1.050 ± 0.038
Cerebellum
GABA	0.055 ± 0.001	0.051 ± 0.001	0.384 ± 0.020	0.265 ± 0.011*
Glutamate	0.044 ± 0.001	0.046 ± 0.001	0.229 ± 0.029	0.082 ± 0.014*
Taurine	0.859 ± 0.028	0.933 ± 0.022	0.826 ± 0.015	0.687 ± 0.018*

The average release rates (±SEM) were calculated for the release periods indicated. Number of independent experiments 8 and release estimates 5 (20–30 min) and 10 (32–50 min). Significance of differences between the early and late release periods: *P < 0.01.