Development of a Novel Cysteine Sulfinic Acid Decarboxylase Knockout Mouse: Dietary Taurine Reduces Neonatal Mortality

Table 3

Survival rate of litters from mating pairs as well as average number of total and surviving pups per litter.

Mating pairs	WT	HT	G1 HO	G2 HO	G2 HOT^1	G3 HO	G3 HOT^2
Number of mating pairs	9	14	10	13	13	10	16
Average number of total pups per litter	5.1±0.8^4	6.2±0.9	6.1±0.7	4.5±0.4	6.4±0.6	4.9±0.6	5.5±0.5
Surviving litters from mating pairs^3	9	14	10	2	12	1	15
Average number of surviving pups per litter	4.9+0.8	6.2+0.9	5.6±0.6	0.9±0.2^∗	5.4±0.7	0.4±0.3^∗	5.3±0.5

¹Mating pairs (G2 HO) were treated with taurine in drinking water (0.05%) 10 days prior to mating.
²Mating pairs born from G2 HOT and treated with taurine after weaning.
³Litters are designated as “surviving litter” if one or more pups grew to weaning.
⁴Mean ± SE.
^∗𝑃<0.002 compared to WT.