Heavy Alcohol Drinking Associated Akathisia and Management with Quetiapine XR in Alcohol Dependent Patients
Table 1
Baseline demographics, drinking history markers, and acute withdrawal assessment in alcohol dependent patients by MADRS group and gender.
Treatment and measures
Low MADRS (clinically nonsignificant)
High MADRS (clinically significant)
Significance between the MADRS grs. ()
Males (63)
Females (14)
Overall (77)
Males (27)
Females (4)
Overall (31)
Age (yrs.)
44.4 ± 10.0
49.9 ± 8.5
45.43 ± 9.919
46.0 ± 8.1
41.8 ± 4.3
45.42 ± 7.749
NS
Weight (lb.)
194.9 ± 40.8
153.2 ± 27.6
187.34 ± 41.8
195.1 ± 35.0
174.3 ± 35.4
192.4 ± 35.2
NS
Drinking history
TD90
1268.9 ± 503.5
1030.0 ± 507.8
1225.5 ± 509.4
1370.0 ± 587.3
1064.8 ± 309.1
1328.8 ± 564.9
NS
AvgDPD90
14.1 ± 5.6
11.4 ± 5.6
13.6 ± 5.6
15.2 ± 6.5
11.8 ± 3.4
14.8 ± 6.2
NS
HDD90
63.1 ± 22.7
72.1 ± 13.1
64.8 ± 21.5
67.7 ± 24.7
76.0 ± 16.2
68.7 ± 23.7
NS
NDD90
80.5 ± 15.1
81.3 ± 13.7
80.62 ± 14.7
79.1 ± 13.6
83.8 ± 6.5
79.7 ± 12.9
NS
Acute withdrawal assessment
CIWA BL
1.7 ± 2.0
1.1 ± 2.4
1.6 ± 2.1
3.6 ± 2.6
3.5 ± 3.5
3.6 ± 2.7
≤0.001
CIWA 6 W
0.9 ± 1.3
0.6 ± 1.2
0.9 ± 1.2
1.1 ± 1.4
0.7 ± 1.2
1.0 ± 1.3
NS
CIWA 12 W
1.1 ± 1.4
0.1 ± 0.3
0.9 ± 1.4
1.1 ± 1.6
1.7 ± 0.6
1.2 ± 1.5
NS
TD90: total drinks in 90 days; AvgDPD90: average drinks per drinking day in last 90 days; HDD90: heavy drinking days in last 90 days; NDD90: number of drinking days in last 90 days.
