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Journal of Applied Mathematics

Volume 2014 (2014), Article ID 258915, 9 pages

http://dx.doi.org/10.1155/2014/258915

## Dynamics of a Stochastic Multigroup SEIR Epidemic Model

College of Automation Science and Engineering, South China University of Technology, Guangzhou 510640, China

Received 1 April 2014; Accepted 1 July 2014; Published 24 July 2014

Academic Editor: Shiping Lu

Copyright © 2014 Xiaojing Zhong and Feiqi Deng. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

#### Abstract

To be more precise about the real world activity, a stochastic multigroup SEIR epidemic model is formulated. we define the basic reproduction number and show that it is a sharp threshold for the dynamics of SDE model. If , the disease-free equilibrium is asymptotically stable; and if , the disease persists and there exists a globally asymptotically stable stationary distribution. Numerical simulation examples are carried out to substantiate the analytical results.

#### 1. Introduction

For the past decades, many epidemic models have been proposed for modeling the spread process of infectious diseases, and in the meantime considerable attention has been paid to study the dynamical properties of these various models. Most models descend from the classical SIR model of Kermack and McKendrick [1]; it is the earliest triumphs in mathematical epidemiology. After that, many researchers worked on epidemic models and established different type of epidemic models [2–10]. In particular, multigroup models have been proposed to describe the transmission dynamics of infectious diseases in heterogeneous host populations, such as meals, mumps, gonorrhea, HIV/AIDS, West-Nile virus, and vector borne diseases such as Malaria. One of the earliest works on multigroup models is the seminal paper by Lajmanovich and Yorke [11] on a class of SIS multigroup models for the transmission dynamics of Gonorrhea; they established a complete analysis of the global dynamics. The global stability of the unique equilibrium is proved by using a complete analysis of the global Lyapunov function. Recently, a group-theoretic approach to the method of global Lyapunov function was proposed by Li and Shuai [12]; they studied the following SEIR model:

The model describes the spread of an infectious disease in a heterogeneous population, which is partitioned into homogeneous group. Each group is further compartmentalized into , , and ; here , , and denote the subpopulation that are susceptible to the disease, infected but noninfectious, and infectious, respectively. All parameters in the above model are nonnegative constants and summarized in the following list: * *: transmission coefficient between compartments and ; * *: nature death rates of , , and compartments in the th group, respectively; * *: influx of individuals into the th group; * *: rate of becoming infectious after latent period in the th group who are immunized; * *: recovery rate of infectious individuals in the th group.

There are two equilibria of this model as disease-free equilibrium , where , and endemic equilibrium . A threshold is defined which decides the epidemic will prevalent or not; here, denote the spectral radius of the matrix

For more details of it, if , then is the unique equilibrium and it is globally asymptotically stable in , where is the limit set of system (1):

If , then is unstable and it is uniformly persistent. Furthermore, there exists an endemic equilibrium and it is globally asymptotically stable in . In the whole proof, it used a very important group theorem [12].

Given a nonnegative matrix , the directed graph associated with has vertices with a directed arc (, ) from to if and only if . It is strongly connected if any two distinct vertices are joined by an oriented path. The matrix is irreducible if and only if is strongly connected. A tree is a connected graph with no cycles. A subtree of a graph is said to be spanning if contains all the vertices of . A directed tree is a tree in which each edge has been replaced by an arc directed one way to the other. A directed tree is said to be rooted at a vertex, called the root, if every arc is oriented in the direction towards the root. An oriented cycle in a directed graph is a simple closed oriented path. A unicyclic graph is a directed graph consisting of a collection of disjoint rooted directed trees whose roots are on an oriented cycle. For a given nonnegative matrix , let be the Laplacian matrix of the directed graph and denote the cofactor of the entry of . In light of these results, complete determination of the global dynamic of these models is essential for their application and further development.

Whereas the statement above, the large-scale biological system's parameters are assumed as constants, but in the real situation, parameters involved with the model always fluctuate around some average value due to continuous fluctuation in the environment. In order to study the dynamics of interacting population under realistic situation, we need to analyse the associated stochastic model. Stochastic epidemic models have been studied by many authors [13–29], Tornatore et al. [23], Yu et al. [24], Ji et al. [25], Liu et al. [26], and Ji et al. [27] using Lyanupov methods to find out sufficient conditions of the stability of the steady-state based on the deterministic threshold . Gray et al. [28] established a stochastic SIS model and found out a sufficient and necessary condition of the disease-free equilibrium. Hasminskii [29] work on the stochastic persistence of epidemic model and give many stochastic persistence definitions about epidemic model.

In the present paper, we introduce white noise into system (1) by perturbing model parameters , , to arrive at the following system of stochastic differential equations: where is standard brownian motions. Our main objective is to derive a sharp threshold for the extinction and persistence of the disease. We proved that the dynamics of our model is determined by a noise modified basic reproduction number: More specifically, if , the disease-free equilibrium is asymptotically stable and the disease dies out. If , then is unstable, system (6) is stochastically persistent, and there exists a stationary distribution. Our definition of includes as a special case of a basic reproduction number for a stochastic SIS model in [22]. From (7), we see that if are nonzero. This implies that the presence of noise lowers the threshold for the extinction of disease and hence results in a larger parameter region for disease to die out. This agrees with an earlier result on stochastic SIS models in [22] and findings on stochastic logistic equations that the presence of noise increases the parameter region in which the species becomes extinct. Unlike the standard approach of using Lyapunov functions in the literature of SDE epidemic models, our stability analysis of applied the method of linearization. And we use the recurrence condition to prove the existence of stationary distribution.

In this paper, we establish the global existence of positive solutions in Section 2. Stability analysis of the disease-free equilibrium is carried out in Section 3. In Section 4, we prove the existence of a globally stable stationary distribution when . Numerical simulations are provided at the end of Sections 3 and 4 to illustrate our analytical results.

#### 2. Existence and Uniqueness of the Positive Global Solution

In this section, we prove the positive global existence of our stochastic system’s (6) solution. As a stochastic differential equation, the functions involved with stochastic system are generally required to satisfy the lipschitz condition and linear growth condition. Obviously, the function of system (6) does not satisfy the linear growth condition, so the solution may explode at a finite time, only if we prove that the explosion time is infinite. We use the lyapunov analysis method to confirm our assumption that the solution of our system is global existence and positive.

Theorem 1. *If is irreducible, then, for any initial value of system (6), there exists a unique solution , and it satisfies
**
which means .*

*Proof. *Since the coefficients of the equation are locally Lipschitz continuous, there is a unique local solution on , where is the explosion time [30]. We assume the solution ; now, we need to prove is global. Let be sufficiently large so that , , all lie within the interval . For each integer , define the stopping time . To complete the proof, we need to show that . If this statement is false, then there are constants , , and , such that for all .

Let denote the cofactor of the th diagonal entry of , which is the Laplacian matrix of and . We define
where is a positive constant. Obviously, is positive. Using Itô’s formula, we obtain
where
where . As is irreducible [12], we know that , which implies that . We define ; then, we obtain
Therefore,
Set . Then, . Note that, for every , there is at least one of that equals either or . Then,
where we define such that . Then, we obtain
Letting , then . So, the assumption is wrong, and we obtain . The proof is complete.

#### 3. Extinction of the Epidemic

In the study of population systems, extinction and persistence are two of the most important issues. For the deterministic model (1), extinction is implied by showing that the disease-free equilibrium is asymptotically stable. For our stochastic model (6), there does not exist the disease-free equilibrium because of the first perturbation term . If , the first equation in (6) changes to For this kind of equations, Gray et al. [21] have shown that the solution satisfies that

We make the change of variables and so that the origin will represent ; then, we consider the linearized system:

To be simplified, we rewrite the second and third equations in (18) as where and are commute, and the explicit solution of the linearized system (18) is where Let denote the spectral radius of the matrix if , which means all the eigenvalue of have negative real parts. Then, there is a pair of positive constants and such that It then follows that Using the strong law of large numbers states that a.s.; we obtain In other words, the solution of (18) is almost surely exponentially stable. Next, we give estimate for , using It’s formula; we derive that According to (19), there exist , . Substituting it to (26), we get

Therefore, In this way, we proved that the solution of (7) is exponentially stable. According to the Oseledec multiplicative ergodic theorem [30], the necessary and sufficient condition for the almost sure asymptotic stability of the trivial solution of the system is the largest lyapunov exponent of the linearized system is negative. Therefore, we have the following results.

Theorem 2. *Assume that is irreducible.**(1) If , then the disease-free equilibrium is almost sure asymptotically stable, which means the disease will die out almost surely.**(2) If , then the disease-free equilibrium is unstable.*

*Remark 3. *It is useful to observe that for either the classical deterministic model or the stochastic model, there is a threshold which reflects the prevalent or extinction of the epidemic, but the thresholds are different between them; the stochastic threshold is smaller then the deterministic one. In other words, the conditions for to become extinct in the SDE epidemic model are weaker than in the classical deterministic epidemic model. We give the following example that illustrates this result more explicitely.

*Example 4. *For simplicity, let and we choose the following system parameters:
so the stochastic multigroup SEIR model (6) becomes
Clearly, if , system (27) becomes the related deterministic multigroup SEIR model. We start our numerical simulation with , and the initial values are . Note that . By Theorem 2, will tend to zero exponentially. If we consider the corresponding deterministic model, , , will tend to their endemic equilibrium. The computer simulation in Figure 1 illustrates extinction of the disease.

Next, we keep the parameter value and start our computer simulation at the initial value ; we gain the same results in Figure 2.

If we decrease the environment intensity to and starting from , this means that . From Theorem 2, the disease-free equilibrium will be unstable; results of one simulation run in Figure 3 proved our results.

#### 4. Stationary Distribution

As we know stochastic persistence means if solution trajectories start from a positive initial condition, then they will remain within the positive interior and bounded at all future times. If we prove the existence of stationary distribution of our stochastic multigroup SEIR model, it means the disease will persist. Before proving the main theorem, we reference to the book by Hasminskii [29]. Let be a regular time-homogeneous Markov process described by the SDE

The diffusion matrix is defined as follows:

Lemma 5. *The Markov process has a unique stationary distribution if there exists an open bounded domain , and the conditions are satisfied.**(P1). In the domain and some neighborhood thereof, the smallest eigenvalue of the diffusion matrix is bounded away from zero.**(P2). If , the mean time at which a path issuing from reaches the set is finite, and for every compact subset . Let be a function integrable with respect to the measure . Then,
**
for all .*

*Remark 6. *The proof of the above lemma is given in Hasminskii [29]. The existence of a stationary distribution with density is given in Theorem 4.1 at page 119 and Lemma 9.4 at page 138.

To validate (P1), it sufficient to prove that is uniformly elliptical in , where , which means there is a positive number such that for any . To validate (P2), it is enough to show that there exist some neighborhood and a nonnegative -function such that, for any , is negative definite function (for details, see page 1163 in [31]).

Theorem 7. *Assume that is irreducible and . There is a stationary distribution for system (7) and it has an ergodic property.*

*Proof. *Since , there is an endemic equilibrium for the deterministic system of (7). We obtain the following equation:
Using the same method in the proof of Theorem 1.1 [7], we choose , , , , , such that . Set
Applying Itô’s formula, we can calculate
Substituting (6) to it and using (31), we obtain
Since , it follows that ; using (31), we obtain
which means
Note that
So, there exists a domain lying entirely in . For , , where is a positive constant. It implies that condition (P2) is satisfied. Besides, there is a such that , which implies that condition (P2) is satisfied. Therefore, according to Lemma 5, our stochastic SEIR model (6) has a stationary distribution and it is ergodic. The proof is complete.

*Example 8. *To substantiate the analytic findings above, we provide numerical simulation results for the stochastic model (27). We also use the same parameters in Example 4, and let . We have shown in Figure 3 that , will not tend to 0. Theorem 4.3 tells us that there is a stationary distribution. Figure 4 shows histograms of the approximate stationary distribution of the infective classes.

#### Conflict of Interests

The authors declare that there is no conflict of interests regarding the publication of this paper.

#### Acknowledgments

The authors would like to thank the editor and the referees for their helpful suggestions and comments. They would also like to thank the National Natural Science Foundation of China Grant no. 61273126, the Natural Science Foundation of Guangdong Province under Grants nos. 10251064101000008 and S201210009675, and the Fundamental Research Funds for the Central Universities 2012ZM0059 for their financial support.

#### References

- W. O. Kermack and A. G. McKendrick, “Contributions to the mathematical theory of epidemics (part 1),”
*Proceedings of the Royal Society of London Series A*, vol. 115, no. 1, pp. 700–721, 1927. View at Google Scholar - B. Song, C. Castillo-Chavez, and J. P. Aparicio, “Tuberculosis models with fast and slow dynamics: the role of close and casual contacts,”
*Mathematical Biosciences*, vol. 180, no. 1-2, pp. 187–205, 2002. View at Publisher · View at Google Scholar · View at MathSciNet · View at Scopus - M. Y. Li, J. R. Graef, L. Wang, and J. Karsai, “Global dynamics of a SEIR model with varying total population size,”
*Mathematical Biosciences*, vol. 160, no. 2, pp. 191–213, 1999. View at Publisher · View at Google Scholar · View at MathSciNet · View at Scopus - M. Y. Li, H. L. Smith, and L. Wang, “Global dynamics an SEIR epidemic model with vertical transmission,”
*SIAM Journal on Applied Mathematics*, vol. 62, no. 1, pp. 58–69, 2001. View at Publisher · View at Google Scholar · View at MathSciNet · View at Scopus - L. Wen and X. Yang, “Global stability of a delayed SIRS model with temporary immunity,”
*Chaos, Solitons and Fractals*, vol. 38, no. 1, pp. 221–226, 2008. View at Publisher · View at Google Scholar · View at MathSciNet · View at Scopus - S. Hsu and L. W. Roeger, “The final size of a SARS epidemic model without quarantine,”
*Journal of Mathematical Analysis and Applications*, vol. 333, no. 2, pp. 557–566, 2007. View at Publisher · View at Google Scholar · View at MathSciNet · View at Scopus - H. B. Guo, M. Y. Li, and Z. S. Shuai, “A graph-theoretic approach to the method of global Lyapunov functions,”
*Proceedings of the American Mathematical Society*, vol. 136, no. 17, pp. 2793–2802, 2008. View at Publisher · View at Google Scholar · View at MathSciNet · View at Scopus - J. Liu and Y. Zhou, “Global stability of an SIRS epidemic model with transport-related infection,”
*Chaos, Solitons and Fractals*, vol. 40, no. 1, pp. 145–158, 2009. View at Publisher · View at Google Scholar · View at MathSciNet · View at Scopus - H.-F. Huo and Z.-P. Ma, “Dynamics of a delayed epidemic model with non-monotonic incidence rate,”
*Communications in Nonlinear Science and Numerical Simulation*, vol. 15, no. 2, pp. 459–468, 2010. View at Publisher · View at Google Scholar · View at MathSciNet · View at Scopus - C. C. McCluskey, “Complete global stability for an SIR epidemic model with delay—distributed or discrete,”
*Nonlinear Analysis. Real World Applications*, vol. 11, no. 1, pp. 55–59, 2010. View at Publisher · View at Google Scholar · View at MathSciNet · View at Scopus - A. Lajmanovich and J. A. Yorke, “A deterministic model for gonorrhea in a nonhomogeneous population,”
*Mathematical Biosciences*, vol. 28, no. 3-4, pp. 221–236, 1976. View at Publisher · View at Google Scholar · View at MathSciNet · View at Scopus - M. Y. Li and Z. Shuai, “Global-stability problem for coupled systems of differential equations on networks,”
*Journal of Differential Equations*, vol. 248, no. 1, pp. 1–20, 2010. View at Publisher · View at Google Scholar · View at Zentralblatt MATH · View at MathSciNet · View at Scopus - D. Jiang and N. Shi, “A note on nonautonomous logistic equation with random perturbation,”
*Journal of Mathematical Analysis and Applications*, vol. 303, no. 1, pp. 164–172, 2005. View at Publisher · View at Google Scholar · View at Zentralblatt MATH · View at MathSciNet · View at Scopus - D. Jiang, N. Shi, and X. Li, “Global stability and stochastic permanence of a non-autonomous logistic equation with random perturbation,”
*Journal of Mathematical Analysis and Applications*, vol. 340, no. 1, pp. 588–597, 2008. View at Publisher · View at Google Scholar · View at Scopus - L. Imhof and S. Walcher, “Exclusion and persistence in deterministic and stochastic chemostat models,”
*Journal of Differential Equations*, vol. 217, no. 1, pp. 26–53, 2005. View at Publisher · View at Google Scholar · View at Zentralblatt MATH · View at MathSciNet · View at Scopus - M. Carletti, “On the stability properties of a stochastic model for phage-bacteria interaction in open marine environment,”
*Mathematical Biosciences*, vol. 175, no. 2, pp. 117–131, 2002. View at Publisher · View at Google Scholar · View at Zentralblatt MATH · View at MathSciNet · View at Scopus - N. Dalal, D. Greenhalgh, and X. Mao, “A stochastic model for internal HIV dynamics,”
*Journal of Mathematical Analysis and Applications*, vol. 341, no. 2, pp. 1084–1101, 2008. View at Publisher · View at Google Scholar · View at MathSciNet · View at Scopus - N. Dalal, D. Greenhalgh, and X. R. Mao, “A stochastic model of {AIDS} and condom use,”
*Journal of Mathematical Analysis and Applications*, vol. 325, no. 1, pp. 36–53, 2007. View at Publisher · View at Google Scholar · View at MathSciNet · View at Scopus - X. R. Mao, G. Marion, and E. Renshaw, “Asymptotic behaviour o f the stochastic Lotka-Volterra model,”
*Journal of Mathematic Analysis Apply*, vol. 287, pp. 141–156, 2003. View at Publisher · View at Google Scholar - X. Mao, G. Marion, and E. Renshaw, “Environmental Brownian noise suppresses explosions in population dynamics,”
*Stochastic Processes and their Applications*, vol. 97, no. 1, pp. 95–110, 2002. View at Publisher · View at Google Scholar · View at Zentralblatt MATH · View at MathSciNet · View at Scopus - A. Gray, H. L. Greenhalgh, X. R. Mao, and J. Pan, “A stochastic differential equation SIS epidemic model,”
*SIAM Journal on Applied Mathematics*, vol. 71, no. 3, pp. 876–902, 2011. View at Publisher · View at Google Scholar · View at MathSciNet · View at Scopus - Q. Yang and X. Mao, “Extinction and recurrence of multi-group SEIR epidemic models with stochastic perturbations,”
*Nonlinear Analysis: Real World Applications*, vol. 14, no. 3, pp. 1434–1456, 2013. View at Publisher · View at Google Scholar · View at MathSciNet · View at Scopus - E. Tornatore, S. M. Buccellato, and P. Vetro, “Stability of a stochastic SIR system,”
*Physica A: Statistical Mechanics and its Applications*, vol. 354, no. 1–4, pp. 111–126, 2005. View at Publisher · View at Google Scholar · View at Scopus - J. Yu, D. Jiang, and N. Shi, “Global stability of two-group SIR model with random perturbation,”
*Journal of Mathematical Analysis and Applications*, vol. 360, no. 1, pp. 235–244, 2009. View at Publisher · View at Google Scholar · View at MathSciNet · View at Scopus - C. Ji, D. Jiang, Q. Yang, and N. Shi, “Dynamics of a multigroup SIR epidemic model with stochastic perturbation,”
*Automatica*, vol. 48, no. 1, pp. 121–131, 2012. View at Publisher · View at Google Scholar · View at Zentralblatt MATH · View at Scopus - H. Liu, Q. Yang, and D. Jiang, “The asymptotic behavior of stochastically perturbed DI SIR epidemic models with saturated incidences,”
*Automatica*, vol. 48, no. 5, pp. 820–825, 2012. View at Publisher · View at Google Scholar · View at MathSciNet · View at Scopus - C. Y. Ji, D. Q. Jiang, and N. Z. Shi, “The behavior of an {SIR} epidemic model with stochastic perturbation,”
*Stochastic Analysis and Applications*, vol. 30, no. 5, pp. 755–773, 2012. View at Publisher · View at Google Scholar · View at MathSciNet · View at Scopus - A. Gray, D. Greenhalgh, L. Hu, X. Mao, and J. Pan, “A stochastic differential equation SIS epidemic model,”
*SIAM Journal on Applied Mathematics*, vol. 71, no. 3, pp. 876–902, 2011. View at Publisher · View at Google Scholar · View at MathSciNet · View at Scopus - R. Z. Hasminskii,
*Stochastic Stability Of Differential Equations*, Sijthoff & Noordhoff, Alphen aan den Rijn, The Netherlands, 1980. - X. R. Mao,
*Stochastic Differential Equations and Applications*, Horwood Publications, Glasgow, UK, 1997. - C. Zhu and G. Yin, “Asymptotic properties of hybrid diffusion systems,”
*SIAM Journal on Control and Optimization*, vol. 49, no. 4, pp. 1155–1179, 2007. View at Publisher · View at Google Scholar · View at MathSciNet · View at Scopus