Research Article

Thermoanalytical Investigation of Some Sulfone-Containing Drugs

Table 1

Thermal decomposition data of TGA, DTG, and DTA curves of Dapsone, dimethyl sulfone, and Topiramate.

DrugsTGA and DTGDTA
1st reaction temperature2nd reaction temperatureEndothermic peaks (°C)Exothermic peaks (°C)
OnsetEnd set%wt lossOnsetEnd set%wt loss

Dapsone339393.4152.174393.4172647.91185.12 (refer to mp), 368.83, 639.34686.34
Dimethyl sulfone170299.1394.53299.133555.71108.81 (refer to mp), 215.9852.23
Topiramate151393.4673.19393.4722.4325.26130.53 (refer to mp), 154.07181.07, 350.80