Thermoanalytical Investigation of Some Sulfone-Containing Drugs

Table 5

Application of the proposed DSC method for determination of the claimed amount of Dapsone, dimethyl sulfone, and Topiramate in their pharmaceutical formulations.

Dosage forms	Claimed amount*  % by the proposed DSC	Claimed amount % by pharmacopoeial and/or reported methods
Dapsone (50 mg of Dapsone/tab)	91.25	96.28^∗∗
MSM (100 mg MSM/tab)	95.36	94.56^∗∗∗
Genuphil tablet (375 mg MSM/tab)	96.33	—
Topamax (25 mg TOP/tab)	93.54	94.26^∗∗∗∗

*Mean of five instrumental run.
**Official BP 2010.
***Manufacturer GC method supplied by Eva Pharma, Egypt.
****Official USP 2012.