Acylation of Chiral Alcohols: A Simple Procedure for Chiral GC Analysis

Table 4

Separation factor values (α) of the enantiomers of some acyclic alcohols and their corresponding acetyl derivatives.

Entry		T (°C)	Alcohol		α	AC		α
			RT			RT
			(−)	(+)		(−)	(+)
1		40	1.83	1.93	1.05	2.94	4.24	1.44	a
2		40	5.10	5.45	1.07	3.79	11.31	3.00	a
3		50	7.61	8.02	1.05	6.35	12.39	1.95	b
4		50	6.79	7.38	1.09	1.35	1.37	1.02	a
5		80	1.92	1.92	1.00	2.32	1.76	1.32	b
6		50	6.91	6.91	1.00	9.04	9.04	1.00	c
7		80	5.36	5.45	1.02	5.04	7.46	1.50	c
8		70	10.18	10.18	1.00	7.53	9.91	1.32	c

T: oven GC temperature (°C); RT: retention time; α: separation factor; AC: acetyl derivatives; the elution order of the acetylated enantiomers was assumed from the literature [34, 35]; a: ¹H and ¹³C NMR spectral data were in agreement with those published in [37]; b: ¹H and ¹³C NMR spectral data were in agreement with those published in [38]; c: ¹H and ¹³C NMR spectral data in the appendix.