Research Article
Effects of Borneol on Pharmacokinetics and Tissue Distribution of Notoginsenoside R1 and Ginsenosides Rg1 and Re in Panax notoginseng in Rabbits
Table 2
The interday and intraday precision and accuracy of the method for the determination of NGR1, GRg1, and GRe (
).
| | Biosample | QC conc
(μg · mL−1) | Intraday | Interday | Extraction recovery | Precision
(R.S.D %) | Accuracy
(mean %) | Precision
(R.S.D %) | Accuracy
(mean %) | Mean ± S.D. | R.S.D % |
| | NGR1 | | | | | | | | | | 0.5 | 10.4 | 96.0 | 13.0 | 92.0 | | 5.1 | | Plasma | 5.0 | 6.7 | 102.0 | 11.1 | 94.0 | | 3.8 | | | 35.0 | 4.2 | 97.4 | 5.4 | 103.7 | | 7.9 | | | 0.5 | 6.3 | 92.5 | 8.4 | 104.9 | | 7.0 | | Heart | 5.0 | 8.3 | 91.8 | 9.3 | 98.9 | | 8.4 | | | 50.0 | 4.9 | 100.3 | 5.3 | 106.1 | | 10.6 | | | 0.5 | 8.7 | 98.1 | 10.6 | 95.8 | | 8.4 | | Liver | 5.0 | 7.5 | 91.4 | 8.3 | 96.6 | | 4.9 | | | 50.0 | 7.1 | 99.6 | 7.8 | 105.6 | | 7.4 | | | 0.5 | 9.5 | 90.0 | 6.3 | 108.3 | | 10.4 | | Brain | 5.0 | 4.2 | 108.3 | 9.7 | 95.7 | | 7.8 | | | 50.0 | 3.7 | 103.5 | 7.9 | 95.6 | | 5.3 | | | 0.5 | 7.4 | 94.2 | 13.1 | 103.7 | | 8.5 | | Lung | 5.0 | 12.1 | 98.6 | 4.8 | 105.5 | | 8.6 | | | 50.0 | 6.7 | 105.8 | 10.2 | 95.4 | | 10.1 | | | 0.5 | 8.2 | 90.2 | 5.4 | 90.8 | | 6.2 | | Kidney | 5.0 | 11.1 | 91.4 | 3.8 | 98.4 | | 4.0 | | | 50.0 | 5.9 | 90.5 | 7.8 | 91.3 | | 5.6 | | GRg1 | | | | | | | | | | 0.4 | 14.3 | 105.1 | 13.5 | 92.5 | | 4.5 | | Plasma | 3.0 | 4.4 | 90.0 | 9.0 | 103.3 | | 8.1 | | | 40.0 | 4.6 | 95.3 | 4.1 | 98.3 | | 5.4 | | | 0.4 | 10.2 | 97.4 | 6.4 | 96.3 | | 10.2 | | Heart | 3.0 | 4.4 | 93.9 | 7.5 | 94.7 | | 7.8 | | | 40.0 | 6.2 | 101.3 | 10.4 | 104.6 | | 8.2 | | | 0.4 | 9.9 | 97.2 | 12.3 | 98.4 | | 7.9 | | Liver | 3.0 | 12.4 | 92.5 | 7.8 | 96.2 | | 10.5 | | | 40.0 | 6.3 | 90.9 | 6.8 | 102.5 | | 12.3 | | | 0.4 | 8.9 | 108.9 | 13.2 | 90.4 | | 6.5 | | Brain | 3.0 | 6.1 | 96.3 | 8.4 | 94.3 | | 5.7 | | | 40.0 | 7.3 | 101.8 | 9.3 | 103.1 | | 8.3 | | | 0.4 | 11.8 | 91.9 | 8.8 | 92.8 | | 8.6 | | Lung | 3.0 | 8.4 | 98.0 | 7.5 | 91.9 | | 4.9 | | | 40.0 | 6.2 | 104.7 | 5.4 | 108.2 | | 7.3 | | | 0.4 | 5.4 | 92.8 | 10.2 | 98.7 | | 10.5 | | Kidney | 3.0 | 7.2 | 91.5 | 5.4 | 90.4 | | 3.8 | | | 40.0 | 6.1 | 99.2 | 6.7 | 92.5 | | 7.6 | | GRe | | | | | | | | | | 0.8 | 8.4 | 103.7 | 11.5 | 97.5 | | 6.7 | | Plasma | 8.0 | 6.6 | 92.5 | 6.2 | 107.5 | | 7.9 | | | 48.0 | 4.2 | 104.7 | 3.8 | 102.9 | | 7.8 | | | 0.8 | 5.4 | 95.8 | 5.8 | 92.6 | | 9.3 | | Heart | 8.0 | 6.8 | 99.4 | 8.3 | 101.5 | | 5.8 | | | 48.0 | 5.5 | 109.1 | 6.7 | 103.8 | | 8.8 | | | 0.8 | 9.1 | 96.8 | 10.8 | 98.3 | | 10.5 | | Liver | 8.0 | 6.8 | 94.5 | 9.6 | 96.1 | | 6.6 | | | 48.0 | 9.1 | 96.8 | 8.4 | 98.0 | | 7.3 | | | 0.8 | 12.1 | 91.0 | 7.7 | 99.5 | | 6.7 | | brain | 8.0 | 8.2 | 109.5 | 13.2 | 104.3 | | 9.3 | | | 48.0 | 7.3 | 104.8 | 9.4 | 93.9 | | 6.8 | | | 0.8 | 7.8 | 92.6 | 9.8 | 96.3 | | 9.4 | | Lung | 8.0 | 8.5 | 96.4 | 11.4 | 101.6 | | 7.7 | | | 48.0 | 4.7 | 95.9 | 7.8 | 94.8 | | 6.9 | | | 0.8 | 6.1 | 91.8 | 8.5 | 92.8 | | 8.1 | | Kidney | 8.0 | 3.3 | 92.2 | 9.0 | 90.6 | | 4.7 | | | 48.0 | 8.9 | 96.4 | 4.5 | 95.4 | | 6.0 |
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