Effects of Borneol on Pharmacokinetics and Tissue Distribution of Notoginsenoside R1 and Ginsenosides Rg1 and Re in Panax notoginseng in Rabbits

Table 3

Stability of of NGR1, GRg1, and GRe in plasma samples and tissue homogenates of rabbits (𝑛=6).

Biosample	QC conc (μg · mL^−1)	Remaining (mean ± S.D.)
		Short-term stability	Long-term stability	Freeze-thaw stability
NGR1
	0.5	98.0±6.2	100.0±8.7	90.4±5.9
Plasma	5.0	96.0±8.4	94.0±6.8	92.8±6.4
	35.0	99.8±3.3	97.0±5.3	96.6±5.5
	0.5	98.2±6.7	103.6±6.5	92.8±6.8
Heart	5.0	94.8±9.5	92.9±4.2	102.5±10.6
	50.0	100.3±7.5	96.6±6.7	96.7±8.7
	0.5	95.1±3.1	92.6±9.1	98.9±7.9
Liver	5.0	94.3±6.7	96.6±6.4	103.8±8.2
	50.0	95.4±8.6	100.9±5.6	99.0±5.0
	0.5	92.3±9.4	101.8±6.8	92.8±6.9
Brain	5.0	98.4±4.4	90.0±9.5	92.2±8.5
	50.0	103.5±9.2	99.0±5.3	95.2±11.4
	0.5	91.2±5.4	97.6±6.8	95.8±9.8
Lung	5.0	96.8±8.3	89.8±4.6	91.9±9.3
	50.0	95.6±5.9	91.6±9.8	96.9±7.5
	0.5	92.4±4.3	91.1±5.4	92.2±7.5
Kidney	5.0	95.8±5.6	94.3±2.8	95.4±8.9
	50.0	90.8±3.7	96.8±9.5	80.9±6.7
GRg1
	0.4	102.0±5.7	92.0±5.7	96.0±3.9
Plasma	3.0	94.0±5.9	86.0±9.7	91.1±8.2
	40.0	102.8±9.6	104.6±5.5	103.6±7.0
	0.4	97.8±8.2	98.3±4.4	91.3±6.1
Heart	3.0	96.3±8.4	95.1±5.2	90.8±9.7
	40.0	92.5±4.8	103.2±6.4	102.3±6.6
	0.4	92.5±7.2	95.6±9.7	93.5±8.9
Liver	3.0	94.8±6.4	92.8±6.8	91.9±2.4
	40.0	93.8±8.4	94.7±5.8	93.8±3.8
	0.4	97.5±5.6	90.2±8.3	95.6±5.7
Brain	3.0	93.7±7.2	105.4±8.7	90.9±6.4
	40.0	90.6±6.4	98.7±7.8	98.3±6.1
	0.4	96.1±4.9	90.5±9.8	96.2±4.5
Lung	3.0	99.0±7.9	92.4±3.7	92.3±4.8
	40.0	92.4±9.2	98.9±5.4	98.0±6.7
	0.4	91.5±6.5	90.8±6.1	90.5±7.8
Kidney	3.0	95.9±4.5	91.6±11.2	94.7±3.7
	40.0	102.1±5.7	95.7±4.6	91.2±10.6
GRg1
	0.4	101.6±9.2	96.0±7.9	105.0±5.8
Plasma	3.0	91.8±7.8	86.0±7.2	103.7±8.5
	40.0	97.3±9.5	104.6±6.3	103.1±7.9
	0.4	98.4±3.9	92.4±5.5	91.9±7.8
Heart	3.0	102.5±6.7	95.3±4.2	95.5±8.3
	40.0	92.8±4.9	93.6±6.8	97.8±5.2
	0.4	95.5±6.1	95.9±8.4	97.2±5.7
Liver	3.0	100.5±3.7	92.4±9.2	93.9±6.5
	40.0	95.8±6.3	96.1±4.5	96.7±7.9
	0.4	92.2±3.8	93.7±6.4	90.5±6.8
Brain	3.0	96.7±5.3	96.0±3.5	92.9±5.4
	40.0	93.8±8.5	97.0±6.8	95.4±6.7
	0.4	96.2±3.9	92.4±6.4	90.9±5.9
Lung	3.0	91.7±5.8	93.5±5.3	97.2±5.8
	40.0	96.4±7.3	97.7±8.7	93.8±7.3
	0.8	93.6±5.7	96.3±4.2	90.7±3.4
Kidney	8.0	95.2±4.2	98.3±7.2	93.8±12.2
	48.0	92.8±3.8	92.9±9.0	92.3±5.8