Effects of Borneol on Pharmacokinetics and Tissue Distribution of Notoginsenoside R1 and Ginsenosides Rg1 and Re in Panax notoginseng in Rabbits

Table 4

The statistical parameters of NGR1, GRg1, and GRe after administration of Panax notoginseng and Panax notoginseng combined with Borneol.

Parameters		Panax notoginseng			Panax notoginseng with Borneol
	NGR1	GRg1	GRe	NGR1	GRg1	GRe
𝛼(min^−1)	0.018±0.008	0.018±0.005	0.020±0.004	0.024±0.005	0.031±0.011	0.027±0.008
𝛽 (min^−1)	0.014±0.003	0.010±0.007	0.010±0.002	0.010 ± 0.003*	0.010 ± 0.001	0.010 ± 0.001
𝑡1/2𝛼 (min)	38.5±4.5	38.5±2.5	35.0±1.9	28.4 ± 3.2**	22.3 ± 3.1**	25.2 ± 2.4**
𝑡1/2𝛽 (min)	47.9±8.1	69.3±12.0	69.3±5.8	69.3 ± 5.2**	69.3 ± 10.7	69.3 ± 15.2
V/F (L · kg^−1)	27.3±8.6	24.5±4.5	20.0±4.7	58.8 ± 6.9**	35.9 ± 8.7*	31.1 ± 6.9*
CL/F (L · min^−1 · kg^−1)	0.488±0.091	0.123±0.067	0.150±0.030	0.506 ± 0.027	0.119 ± 0.040	0.143 ± 0.054
AUC0-𝑡 (mg · L^−1 · min^−1)	162.1±42.7	494.8±46.5	424.9±79.6	306.3 ± 82.9**	545.1 ± 51.7	525.1 ± 101.3
AUC0-∞ (mg · L^−1 · min^−1)	164.0±51.8	651.9±73.9	534.7±123.8	395.3 ± 101.4**	1674.6 ± 148.2**	1400.6 ± 251.9**
K 10 (min^−1)	0.018±0.005	0.005±0.001	0.007±0.003	0.009 ± 0.002*	0.003 ± 0.00	0.005 ± 0.001
K 12 (min^−1)	0.000±0.000	0.011±0.003	0.012±0.004	0.015 ± 0.005**	0.025 ± 0.005**	0.022 ± 0.005**
K 21 (min^−1)	0.014±0.007	0.012±0.003	0.011±0.005	0.011 ± 0.002	0.013 ± 0.001	0.011 ± 0.003
K a (min^−1)	0.060±0.004	0.039±0.004	0.025±0.004	0.037 ± 0.005**	0.051 ± 0.010*	0.034 ± 0.003**
𝐶max (mg · L^−1)	2.12±0.46	2.36±0.15	1.92±0.22	1.62 ± 0.30	2.87 ± 0.34**	3.04 ± 0.24**
𝑇max (min)	45.0±9.8	30.0±5.2	45.0±0.0	30.0 ± 8.0*	30.0 ± 0.0	45.0 ± 13.4
𝑡1/2𝐾𝑎(min)	11.6±2.4	17.8±2.4	27.7±3.7	18.8 ± 3.1**	13.5 ± 4.6	20.3 ± 4.2**
𝑇lag (min)	2.38±0.49	0±0	0±0	1.04 ± 0.21**	1.25 ± 0.34**	0.61 ± 0.47*

^∗𝑃<0.05, **𝑃<0.01 compared with Panax notoginseng.