Effects of Borneol on Pharmacokinetics and Tissue Distribution of Notoginsenoside R1 and Ginsenosides Rg1 and Re in Panax notoginseng in Rabbits

Table 5

Drug concentrations in rabbit tissues after administration of Panax notoginseng and Panax notoginseng combined with Borneol (𝑛=6).

Time (ℎ)	Biosample	Concentration (μg · g^−1)
		Panax notoginseng			Panax notoginseng with Borneol
		NGR1	GRg1	GRe	NGR1	GRg1	GRe
0.5	Heart	3.90 ± 0.53	2.21 ± 0.76	1.65 ± 0.53	4.68 ± 0.21**	22.65 ± 0.36**	2.81 ± 0.74**
	Liver	1.38 ± 0.54	8.48 ± 0.53	0.99 ± 0.33	8.24 ± 0.42**	50.10 ± 1.95**	3.60 ± 0.46**
	Brain	0.65±0.24	0.75±0.11	1.05 ± 0.42	4.02 ± 0.46**	20.57 ± 1.36**	1.80 ± 0.42*
	Lung	1.77±0.46	14.30±0.43	0.70 ± 0.41	5.79 ± 0.29**	15.09 ± 3.24**	2.48 ± 0.69**
	Kidney	2.85±0.45	4.05±0.26	1.63 ± 0.18	3.98 ± 0.12**	27.54 ± 0.17**	2.84 ± 0.53**
	Plasma (μg · mL^−1)	1.67±0.05	1.97±0.16	1.78 ± 0.11	1.62 ± 0.07	2.87 ± 0.06**	2.68 ± 0.13**
1.0	Heart	4.26±0.27	2.94±0.24	2.11 ± 0.28	5.55 ± 0.31**	27.03 ± 0.31**	3.28 ± 0.43**
	Liver	1.66±0.28	8.85±0.51	1.30 ± 0.25	9.29 ± 0.72**	59.05 ± 3.74**	4.77 ± 0.42**
	Brain	0.81±0.26	0.91±0.89	1.21 ± 0.28	5.58 ± 0.68**	25.66 ± 2.69**	2.76 ± 0.63**
	Lung	1.82±0.20	15.32±0.64	0.92 ± 0.13	9.96 ± 0.66**	17.80 ± 1.25**	2.99 ± 0.17**
	Kidney	2.74±0.33	3.67±0.38	1.53 ± 0.22	3.38 ± 0.34**	16.93 ± 0.81**	2.43 ± 0.29**
	Plasma (μg · mL^−1)	1.29±0.20	1.99±0.06	1.90 ± 0.15	1.46 ± 0.05	2.18 ± 0.09**	2.42 ± 0.08**
3.0	Heart	3.31±0.32	1.53±0.45	1.14 ± 0.13	4.59 ± 0.52**	19.07 ± 1.16**	2.24 ± 0.54**
	Liver	0.89±0.12	6.18±0.59	0.69 ± 0.11	6.87 ± 0.61**	37.78 ± 3.43**	2.63 ± 0.81**
	Brain	0.48±0.14	0.57±0.20	0.63 ± 0.12	3.69 ± 0.84**	17.86 ± 2.60**	1.65 ± 0.23**
	Lung	1.51±0.16	11.87±0.71	0.31 ± 0.44	4.56 ± 0.75**	12.31 ± 1.46	1.53 ± 0.45**
	Kidney	1.94±0.24	3.03±0.23	1.15 ± 0.13	2.27 ± 0.28	10.16 ± 2.77**	1.61 ± 0.45
	Plasma (μg · mL^−1)	0.16±0.06	0.98±0.01	0.79 ± 0.02	0.49 ± 0.02	0.92 ± 0.01	0.87 ± 0.04

^∗∗𝑃<0.01 compared with Panax notoginseng.