Research Article
Effects of Borneol on Pharmacokinetics and Tissue Distribution of Notoginsenoside R1 and Ginsenosides Rg1 and Re in Panax notoginseng in Rabbits
Table 5
Drug concentrations in rabbit tissues after administration of
Panax notoginseng and
Panax notoginseng combined with Borneol (
).
| Time () | Biosample | Concentration (μg · g−1) | | Panax notoginseng | Panax notoginseng with Borneol | | NGR1 | GRg1 | GRe | NGR1 | GRg1 | GRe |
| 0.5 | Heart | 3.90 ± 0.53 | 2.21 ± 0.76 | 1.65 ± 0.53 | 4.68 ± 0.21** | 22.65 ± 0.36** | 2.81 ± 0.74** | Liver | 1.38 ± 0.54 | 8.48 ± 0.53 | 0.99 ± 0.33 | 8.24 ± 0.42** | 50.10 ± 1.95** | 3.60 ± 0.46** | Brain | | | 1.05 ± 0.42 | 4.02 ± 0.46** | 20.57 ± 1.36** | 1.80 ± 0.42* | Lung | | | 0.70 ± 0.41 | 5.79 ± 0.29** | 15.09 ± 3.24** | 2.48 ± 0.69** | Kidney | | | 1.63 ± 0.18 | 3.98 ± 0.12** | 27.54 ± 0.17** | 2.84 ± 0.53** | Plasma (μg · mL−1) | | | 1.78 ± 0.11 | 1.62 ± 0.07 | 2.87 ± 0.06** | 2.68 ± 0.13** |
| 1.0 | Heart | | | 2.11 ± 0.28 | 5.55 ± 0.31** | 27.03 ± 0.31** | 3.28 ± 0.43** | Liver | | | 1.30 ± 0.25 | 9.29 ± 0.72** | 59.05 ± 3.74** | 4.77 ± 0.42** | Brain | | | 1.21 ± 0.28 | 5.58 ± 0.68** | 25.66 ± 2.69** | 2.76 ± 0.63** | Lung | | | 0.92 ± 0.13 | 9.96 ± 0.66** | 17.80 ± 1.25** | 2.99 ± 0.17** | Kidney | | | 1.53 ± 0.22 | 3.38 ± 0.34** | 16.93 ± 0.81** | 2.43 ± 0.29** | Plasma (μg · mL−1) | | | 1.90 ± 0.15 | 1.46 ± 0.05 | 2.18 ± 0.09** | 2.42 ± 0.08** |
| 3.0 | Heart | | | 1.14 ± 0.13 | 4.59 ± 0.52** | 19.07 ± 1.16** | 2.24 ± 0.54** | Liver | | | 0.69 ± 0.11 | 6.87 ± 0.61** | 37.78 ± 3.43** | 2.63 ± 0.81** | Brain | | | 0.63 ± 0.12 | 3.69 ± 0.84** | 17.86 ± 2.60** | 1.65 ± 0.23** | Lung | | | 0.31 ± 0.44 | 4.56 ± 0.75** | 12.31 ± 1.46 | 1.53 ± 0.45** | Kidney | | | 1.15 ± 0.13 | 2.27 ± 0.28 | 10.16 ± 2.77** | 1.61 ± 0.45 | Plasma (μg · mL−1) | | | 0.79 ± 0.02 | 0.49 ± 0.02 | 0.92 ± 0.01 | 0.87 ± 0.04 |
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compared with Panax notoginseng.
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