Effects of Borneol on Pharmacokinetics and Tissue Distribution of Notoginsenoside R1 and Ginsenosides Rg1 and Re in Panax notoginseng in Rabbits

Table 6

Apparent permeability coefficients (𝑃_app) of NGR1, GRg1, and GRe with or without the addition of 200 μM Borneol on the Caco-2 Model.

Compound	𝑃app (apical to basolateral) (× 10^−7 cm/s)	𝑃app (basolateral to apical) (× 10^−7 cm/s)	𝐸𝑟
NGR1	0.64 ± 0.08	0.68 ± 0.12	1.06
GRg1	3.48 ± 0.42	3.64 ± 0.29	1.05
GRe	5.46 ± 0.40	5.73 ± 0.37	1.05
NGR1 + Borneol	1.87 ± 0.23**	1.95 ± 0.34**	1.04
GRg1 + Borneol	9.05 ± 0.67**	9.51 ± 0.62**	1.05
GRe + Borneol	12.67 ± 1.01**	13.65 ± 1.59**	1.08

^∗𝑃<0.05, **𝑃<0.01 compared with corresponding single compound such as NGR1, GRg1, or GRe.