Research Article
Validation and Application of a New Reversed Phase HPLC Method for In Vitro Dissolution Studies of Rabeprazole Sodium in Delayed-Release Tablets
Table 6
Robustness of the method.
| Parameters | Variance | Amount added (μg/mL) | Retention time (min) | Mean area of peak ± %RSD, = 3 | Standard | Sample |
| Flow rate | 0.9 mL/min | 10 | 2.8 | 219467 ± 0.3 | 225203 ± 0.4 | 1.1 mL/min | 10 | 2.2 | 184626 ± 0.3 | 188516 ± 0.3 | Organic (%) in mobile phase | 59 | 10 | 2.7 | 207066 ± 0.5 | 206049 ± 0.3 | 61 | 10 | 2.5 | 203858 ± 0.3 | 203051 ± 0.4 | Detector wavelength | 278 nm | 10 | 2.7 | 199421 ± 0.2 | 198228 ± 0.6 | 282 nm | 10 | 2.7 | 213519 ± 0.4 | 211768 ± 0.7 |
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