Determination of (4E,6E,12E)-Tetradecatriene-8,10-diyne-1,3-diyl Diacetate in Rat Plasma and Tissues by HPLC-UV Method and Their Application to a Pharmacokinetic and Tissue Distribution Study

Table 2

The pharmacokinetic parameters of (4E,6E,12E)-tetradecatriene-8,10-diyne-1,3-diyl diacetate of raw and processed AtractylodisRhizoma at a dose of 40 g·kg⁻¹ to rats, respectively (𝑛=6).

Parameters	Raw	Processed
AUC(0-𝑡) (mg·h·L^−1)	0.260 ± 0.137	0.265 ± 0.100
AUC(0-∞) (mg·h·L^−1)	0.317 ± 0.157	0.303 ± 0.111
MRT(0-𝑡) (h )	7.706 ± 0.888	7.384 ± 0.86
MRT(0-𝑡) (h)	14.86 ± 6.813	12.22 ± 3.364
𝑡1/2𝑧 (h)	9.905 ± 7.382	8.047 ± 3.347
𝑇max (h)	2.333 ± 0.816	1.000 ± 0.817
𝐶max (mg·L^−1)	0.038 ± 0.024	0.042 ± 0.017