Research Article
Studies on the Anti-Inflammatory Effect and Its Mechanisms of Sophoridine
Table 3
The influences of SRI on the production of TNF
, IL-6, IL-8, and PGE
2 in the local inflammatory exudates of carrageenin-induced mouse paw edema model
.
| Group | Dosage (mg/kg) |
TNF (OD value) (mean ± SD) |
IL-6 (OD value) (mean ± SD) |
PGE2 (OD value) (mean ± SD) |
IL-8 (ng/mL) (mean ± SD) | Inhibition (%) | TNF | IL-6 | PGE2 | IL-8 |
| Control | | 0.680 ± 0.011 | 1.341 ± 1.156 | | | | | | | Model | | 0.532 ± 0.023 | 3.379 ± 0.261 | 0.303 ± 0.008 | 0.267 ± 0.081 | | | | | Ibuprofen | 176.5 | 0.437 ± 0.025(2) | 2.413 ± 0.210 | 0.170 ± 0.029(2) | 0.146 ± 0.042(2) | −64.5 | 28.6 | 43.7 | 45.3 | SRI | 48.60 | 0.564 ± 0.030 | 3.167 ± 0.090(2) | 0.193 ± 0.011(2) | 0.210 ± 0.044(1) | 21.6 | 6.3 | 36.4 | 21.3 | SRI | 12.15 | 0.547 ± 0.022 | 3.132 ± 0.157(1) | 0.218 ± 0.040(1) | 0.256 ± 0.073 | 10.1 | 7.3 | 27.9 | 4.1 |
|
|
Compared with model group, (1), (2).
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