Review Article
Solid Phase Microextraction and Related Techniques for Drugs in Biological Samples
Table 4
Applications of monolithic methacrylate polymer packed 96-tip.
| Compound class/compound | Sample matrix | Sample volume (L) | Analytical method | Calibration range | References |
| Local anaesthetics | | | | | | Lidocaine | Human plasma | 100 | LC-MS/MS | 14–5000 nM | [154] | Ropivacaine | Human plasma | 100 | LC-MS/MS | 2–2000 nM | [155] | Bupivacaine | Human plasma | 100 | LC-MS/MS | 2–2000 nM | [156] | Anticancer drugs | | | | | | Cyclophosphamide | Mice blood | 20 | LC-MS/MS | 10–2000 nM | [159] | Busulphan | Human blood | 100 | LC-MS | 5–2000 nM | [159] | Roscovitine | Human plasma | 100 | LC-MS/MS | 14–5000 nM | [154] | -Blockers | | | | | | Pindolol | Human plasma | 100 | LC-MS/MS | 0.5–5000 nM | [157, 158] | Metoprolol | Human plasma | 100 | LC-MS/MS | 0.5–5000 nM | [157, 158] |
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