Solid Phase Microextraction and Related Techniques for Drugs in Biological Samples

Table 4

Applications of monolithic methacrylate polymer packed 96-tip.

Compound class/compound	Sample matrix	Sample volume (𝜇L)	Analytical method	Calibration range	References
Local anaesthetics
Lidocaine	Human plasma	100	LC-MS/MS	14–5000 nM	[154]
Ropivacaine	Human plasma	100	LC-MS/MS	2–2000 nM	[155]
Bupivacaine	Human plasma	100	LC-MS/MS	2–2000 nM	[156]
Anticancer drugs
Cyclophosphamide	Mice blood	20	LC-MS/MS	10–2000 nM	[159]
Busulphan	Human blood	100	LC-MS	5–2000 nM	[159]
Roscovitine	Human plasma	100	LC-MS/MS	14–5000 nM	[154]
𝛽-Blockers
Pindolol	Human plasma	100	LC-MS/MS	0.5–5000 nM	[157, 158]
Metoprolol	Human plasma	100	LC-MS/MS	0.5–5000 nM	[157, 158]