Applied Circular Dichroism: A Facile Spectroscopic Tool for Configurational Assignment and Determination of Enantiopurity

Figure 2

CD standard curves of not-over-the-counter available substances: (a) alanine and (b) thalidomide. The spectra were measured for solutions of increasing concentration of the R-enantiomer from 0 to 100% as shown in the legend for both compounds. Insets are linear regression graphs showing between enantioenrichments versus at the wavelength of maximum absorption. All analytes were dissolved in methanol at 0.3 mM concentrations. All readings were determined at room temperature.

(a) Alanine CD spectra

(b) Thalidomide CD spectra