Applied Circular Dichroism: A Facile Spectroscopic Tool for Configurational Assignment and Determination of Enantiopurity

Figure 3

CD spectra of varying enantioenrichment of the R-enantiomer (0–100%) for OTC available substances: (a) ibuprofen, (c) pseudoephedrine, and the OTC drugs of (b) Motrin, Advil and Equate ibuprofen, (d) Sudafed and Suphedrine at 0.3 mM concentration in methanol with a corresponding linear regression between enantioenrichment and at the wavelength of maximum absorption shown in the inset. All readings were taken at room temperature.