Fast HPLC-MS/MS Method for Determining Penicillin Antibiotics in Infant Formulas Using Molecularly Imprinted Solid-Phase Extraction

Table 2

Composition of different MIP synthesized for the simultaneous extraction of penicillin drugs.

Template	Functional monomer	Cross-linkers	Porogens	Initiator	Polymerization problems
Oxacillin		DVB	ACN/TOL	AIMN	Not dissolved
		EGDMA	MeOH	AIMN
Amoxicillin		DVB	ACN/TOL	AIMN	Not dissolved
		EGDMA	MeOH	AIMN
Nafcillin	MAA	DVB	ACN/TOL	AIMN
		TRIM	ACN	AIMN
		TRIM	MeOH	AIMN
		EGDMA	ACN	AIMN
		EGDMA	MeOH	AIMN

MAA: methacrylic acid; EGDMA: ethylene glycol dimethacrylate; DVB: divinylbenzene; AIMN: 2,2′-azobis-(2-methylbutyronitrile); TRIM: trimethylolpropane trimethacrylate; MeOH: methanol; ACN: acetonitrile; TOL: toluene.