Research Article
Fast HPLC-MS/MS Method for Determining Penicillin Antibiotics in Infant Formulas Using Molecularly Imprinted Solid-Phase Extraction
Table 3
MRM transitions of each analyte and collision energy (CE) for mass spectrometry detection and chromatographic retention time.
| Compound | Mw | Precursor ion | Fragment ion | CE (volts) | RT |
| Amoxicillin | 365.4 | 366 | 349 | 13 | 2.1 | 114 | 25 | |
| Oxacillin | 401.4 | 402 | 144 | 33 | 14.5 | 186 | 21 | |
| Cloxacillin | 435.9 | 436 | 178 | 31 | 14.9 | 220 | 21 | |
| Penicillin G | 334.4 | 335 | 217 | 17 | 12.9 | 202 | 31 | |
| Penicillin V | 350.4 | 351 | 229 | 19 | 13.7 | 257 | 17 | |
| Ampicillin | 349.4 | 350 | 106 | 21 | 6.4 | 160 | 9 | |
| Dicloxacillin | 470.3 | 470 | 212 | 33 | 15.7 | 254 | 23 | |
| Nafcillin | 414.4 | 415 | 199 | 17 | 15.2 | 171 | 51 | |
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CE: collision energy in volts.
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