High-Throughput Analysis of Lidocaine in Pharmaceutical Formulation by Capillary Zone Electrophoresis Using Multiple Injections in a Single Run

Figure 1

(a) Structure of lidocaine. (b) Effective mobility curves for lidocaine (-■-), TRIS (-●-), and MES (-▲-). (c) Electropherogram of a pharmaceutical formulation using the optimized method by CZE with multiple injections. Peaks: 1: benzylamine (IS); 2: lidocaine; A, B, C, and D represent the first, second, third, and fourth injection, respectively. BGE composed by TRIS 20 mmol L⁻¹ and MES 40 mmol L⁻¹ at pH 6.1. EOF mobility measured 33.1 × 10⁻⁹ m² V⁻¹ s⁻¹.

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