A Reliable and Effective UPLC-MS/MS Method for the Determination of Oprozomib in Rat Plasma

Figure 2

Representative chromatograms of oprozomib and IS in rat plasma: (a) blank plasma; (b) blank plasma spiked with standard solution at LLOQ (1.0 ng/mL) and IS; (c) sample obtained from a rat after oral administration of 21 mg/kg oprozomib.

(a)

(b)

(c)