A Reliable and Effective UPLC-MS/MS Method for the Determination of Oprozomib in Rat Plasma

Table 2

Recovery and matrix effect of oprozomib in rat plasma (n = 5).

Analyte	Concentration added (ng/mL)	Recovery (%)		Matrix effect (%)
		Mean ± SD	RSD (%)	Mean ± SD	RSD (%)
Oprozomib	2.0	85.1 ± 7.1	8.4	110.4 ± 11.5	10.4
	40	94.5 ± 3.5	3.7	109.7 ± 9.9	9.0
	80	96.1 ± 1.6	1.7	106.8 ± 8.8	8.3

SD: standard deviation; RSD: relative standard deviation.