A Reliable and Effective UPLC-MS/MS Method for the Determination of Oprozomib in Rat Plasma

<table class="table-group" id="tab4"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr class="thead"><td class="align_left">Parameters</td><td class="align_center">Oprozomib</td></tr><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td class="align_left">AUC<sub>0⟶t</sub> (ng/mL•h)</td><td class="align_center">134.6 ± 52.6</td></tr><tr><td class="align_left">AUC<sub>0⟶∞</sub> (ng/mL•h)</td><td class="align_center">144.0 ± 55.5</td></tr><tr><td class="align_left"><i>t</i><sub>1/2</sub> (h)</td><td class="align_center">13.8 ± 8.3</td></tr><tr><td class="align_left"><i>T</i><sub>max</sub> (h)</td><td class="align_center">1.1 ± 0.3</td></tr><tr><td class="align_left">CLz/F (L/h/kg)</td><td class="align_center">172.9 ± 85.5</td></tr><tr><td class="align_left"><i>C</i><sub>max</sub> (ng/mL)</td><td class="align_center">46.5 ± 20.1</td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td><div>AUC: area under the plasma concentration-time curve; <i>t</i><sub>1/2</sub>: elimination half time; <i>T</i><sub>max</sub>: peak time; CLz/F: plasma clearance; <i>C</i><sub>max</sub>: maximum plasma concentration. RSD: relative standard deviation; RE: relative error.<br/></div></td></tr></table>

<div>The main pharmacokinetic parameters of oprozomib in rat plasma after oral administration of oprozomib at a single dose of 21 mg/kg (<i>n</i> = 6, mean ± SD).</div>

Journal of Analytical Methods in Chemistry

tab4

Table 4

Table 4: A Reliable and Effective UPLC-MS/MS Method for the Determination of Oprozomib in Rat Plasma 