Journal of Angiology The latest articles from Hindawi Publishing Corporation © 2014 , Hindawi Publishing Corporation . All rights reserved. Pregnancy-Associated Plasma Protein-A Levels and Coronary Angiographic Features in Acute Coronary Syndrome Patients Tue, 04 Feb 2014 08:52:53 +0000 Background. Pregnancy-associated plasma protein-A (PAPP-A) is a biomarker of plaque rupture, associated with adverse cardiac events in acute coronary syndromes (ACSs) patients. Aim. To identify coronary angiographic (CA) features related to PAPP-A level elevation in ACSs patients. Methods. Forty ACSs patients were enrolled in this prospective cohort study (level of evidence: III-prognostic). Serum samples for PAPP-A quantitation were obtained upon coronary care unit admission. All patients underwent CA and coronary intervention within 6 hours of sampling. Results. Mean age of the study cohort was 57 ± 11 years, (males: 55%, ). Patients with ST-segment elevation myocardial infarction (35%, ) showed significantly higher serum PAPP-A level (11.8 ± 2 µg/mL), compared to non-ST-segment elevation myocardial infarction (15%, ) and unstable angina (50%, ) patients (11 ± 2.6 µg/mL and 8.7 ± 2.3 µg/mL, resp., ). Higher PAPP-A levels were significantly associated with complex culprit lesion morphology (11.8 ± 2 µg/mL for type C lesions, 9.7± 2.5 µg/mL and 7.3 ± 3.5 µg/mL for type B and type A lesions, resp., ), while no relationship to number of diseased coronaries. Conclusion. Higher PAPP-A levels in ACSs patients are associated with unfavorable coronary anatomy and complex angiographic plaque features. Mohamed Shehata Copyright © 2014 Mohamed Shehata. All rights reserved. Medium-Term Results of Treatment for Complicated Acute Type B Dissection: A Spanish Experience in a Single Centre Wed, 15 Jan 2014 15:47:04 +0000 Objective. To analyze and evaluate medium-term results obtained in endovascular treatment of complicated type B dissection. Methods. Prospective registry and retrospective analysis of the dissections treated with endoprosthesis in 1998 and 2010. Comorbidity, clinical presentation, anatomical characteristics, and evolution were recorded. Actuarial analysis was conducted for survival, follow-up and survival free of endoleaks, and free of reintervention due to relapse and/or progression. Results. Eighteen (18) patients were treated (14 male : 4 female), with a median age of 53 years (range 29–80). Their main symptoms were acute pain in 16 cases and hypertensive crisis in 15. The indications were 10 dissections not controlled by medication, 4 aneurysm dissecans, 2 acute lower limb ischemias, and 2 Type A progressions. Median 1.7 devices were used (range 1–4). Coverage of left subclavian artery was required in 3 cases, and of subclavian and left carotid artery in other 2 cases. There was a 100% technical success. Median follow-up was 43.1 months (1.5–127 range). There were two deaths caused by multiorganic failure, early mortality of 0%, and hospital mortality of 11%. There was a case of Type I Endoleak and 5 cases which required a new intervention due to relapse and/or progression. Cumulative survival at 30 months was 88%; follow-up free of endoleaks at 36 months was 91%. Follow-up free of progression/relapse at 12 months was 88%. Conclusion. Endovascular treatment of complicated type B acute dissection is an effective therapy for this condition, with a low associated mortality and with acceptable survival. Jesus Alvarez-Garcia, Stefan Stefanov Kiuri, Alvaro Fernandez Heredero, Andres Salazar Alvarez, Nieves Aleicel Concepcion Rodriguez, and Luis Riera de Cubas Copyright © 2014 Jesus Alvarez-Garcia et al. All rights reserved. Study of the Influence of Upper Extremities Variation on Transradial Success Sun, 22 Sep 2013 14:40:18 +0000 Background. To investigate whether the presence of arterial anomalies in upper limb arteries can influence the success rate of transradial coronary angiography. Methods. retrograde transarterial sheath injection was done in patients with transradial coronary angiography. Arterial anomalies in the upper limb are evaluated in these patients. There are ten brachial (5.4%), 7 radial (4/2%), 5 subclavian (3%), and 3 brachiocephalic arteries (1.8%). There also were 4 loops in ulnar artery (2.4%) and one in radial (0.6%). Except cannulation time (), there were associations between anomalies and other times () and contrast volume used (). Anomalies did not have any effect on procedural success rate and just in one patient because of subclavian loop,procedure changed to femoral approach (). Discussion. Patients without upper extremities anomalies in comparison with patients with anomalies had significantly shorter periods for angiographic time, catheterization time, and fluoroscopic time. We recommend femoral catheterization instead of radial catheterization in patients with upper extremities anomalies. Saeed Yazdankhah, Ahmadreza Assareh, Mehdi Easapour, Mohammad Nourizadeh, and Farzad Daeenejad Copyright © 2013 Saeed Yazdankhah et al. All rights reserved. Anticoagulation for Atrial Fibrillation: Is This the End of Warfarin? Not Just Yet Mon, 12 Aug 2013 19:07:47 +0000 Atrial fibrillation (AF) is the most common cardiac arrhythmia. Its prevalence is known to increase with age and with an aging population AF is likely to become even more common. Although sometimes patients with AF remain asymptomatic, it is now recognized that AF is far from “benign” conferring a significant risk increase in morbidity and mortality. Restoration of sinus rhythm and rate-limiting medication help with symptoms; however, anticoagulation remains essential in reducing thromboembolic risk. The uptake of appropriate anticoagulation with vitamin K antagonists has increased significantly in the last few decades and this review will analyze whether the new oral anticoagulants might prove to be even more effective than existing vitamin K antagonists. Michael Mallouppas and Vassilios Vassiliou Copyright © 2013 Michael Mallouppas and Vassilios Vassiliou. All rights reserved. Fibrous Cap Smooth Muscle Cells in Atherosclerotic Coronary Arteries Do Not Express Pluripotent Stem Cell Markers Mon, 12 Aug 2013 14:16:09 +0000 Rupture of the coronary artery fibrous cap is a common cause of myocardial infarction, and bone marrow derived cells could play a role in preventing plaque rupture. It is currently unknown whether smooth muscle cells within coronary artery fibrous cap formation are of mature phenotype. Objective. To characterize cells expressing bone marrow stem cells of embryonic type (ESC) markers in coronary artery fibrous cap formation. Design. New Zealand White rabbits were fed a diet supplemented with 0.5% cholesterol  +  1% methionine  +  5% peanut oil for 4 weeks and then a normal diet for 9 weeks. The left main coronary artery was excised from the heart, processed for paraffin and immunohistochemistry was performed by standard techniques. Results. Oct-4, SSEA 1, 3, and 4 were all present within in atherosclerotic plaque core, codistributed with RAM-11, and were sparingly found in the fibrous cap, but TRA-1-60 and TRA-1-81 positive cells were scarce. Core but not fibrous cap smooth muscle (SMC actin+) cells also showed codistribution with ESC markers. Conclusions. These results suggest that smooth muscle cells present in the fibrous cap do not express ESC markers, indicative of a mature cell. Melanie Sullivan and Anthony Zulli Copyright © 2013 Melanie Sullivan and Anthony Zulli. All rights reserved.