Sirtuins, Bioageing, and Cancer

Table 2

Cancers associated with Sirtuins and their proposed mechanism of involvement.

Association with cancer
Sirt1	Acute myeloid leukemia, colon, nonmalignant skin, bladder, prostate ovarian cancers, and glioma—mediates p53 function
Sirt2	Glioma—control of cell cycle progression
Sirt3	Breast cancer—decrease in levels is associated with a general increase in tumour growth due to increase in ROI
Sirt4	Breast cancer—metabolic
Sirt5	Pancreatic, breast cancers—metabolic
Sirt6	Colon, breast cancers—mediates NFκB and GCIP function
Sirt7	Breast cancer—mediates p53 function